Pancreas is an organ situated between the stomach and the backbone. Pancreas secretes juices into the first part of the small intensitne and thereby helps in the digestion of food. Addionally, Islet cells of the pancreas secrete the hormone insulin into the blood stream therby playing a major role in glucose homoeostasis.
Cancer refers to abnormal and uncontrolled proliferation of normal cells that results in the formation of a localized primary tumor. In some cases these primary tumor cells detatch themselves from the tumor, enter the circulation and migrate to other tissues, a process called metastasis. Transformation of a normal cell into a cancerous cell can be due to complex mechanisms including alterations in gene expression, incorporation of multiple mutations resulting in altering the switches of signalling cascades and immortality.
Pancreatic cancer is the 4th leading cause of cencer related deaths in USA. As it is diagnozed at a late stage the survival rate of patients is quiet low as compared to other cancers. Incidence and mortality rates are higher in certain ethnic groups in USA in a study by NCI (National cancer Institute). Smoking predisposes individuals to Pancreatic cancer, 20% of the cases reported are due to smoking. Other factors include diabetes, enlarged spleen and other Heriditary factors.
1. Surgical removal of tumors
4. Targeted therapy
Presently, outcome of three clinical trials include the following
1. Gemcitabine improves survival of pateients post surgery
2. Chemotherapy improves the survival in advanced stage patients
3. Targeted therapy - Sunitinib and everolimus
Therefore, identification of Pancreatic cancer at an early stage followed by Targeted therapy [Identification of new targets] is the path forward to deal with this cancer.
Ref: National Cancer Institute
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Top Secret: On Confidentiality On Scientific Issues, Across The Ring And Across The Bedroom
- The Mystery Of The Red Sea
- Stop Using BMI To Determine Health
- Would New Planet X Clear Its Orbit? - And Any Better Name Than "Planet Nine"?
- The Greenhouse Effect Fallacy
- Intense Work Helped Michelangelo Maintain Use Of Hands Despite Osteoarthritis
- Choose the next topic
- "Greetings Robert. Thanks again for your thoughts on God. I read your two statements and here are..."
- "Hello Vance,yes I know about that model, and about at least two experimental attempts, one with..."
- "No, I am not from the states. It sounds like an astonishing arrangement to have multiple jurisdiction..."
- "Very true. The observation I've made is that in 2001 it was John F. Nash and Alicia DeLarde ..."
- "The male female difference you think is so basic isn't so simple. Consider this bird. http..."
- BMI is Bologna
- Energy Drinks: The Dose Makes the Poison
- California’s Prop 65: Bad For Public Acceptance Of Science, About To Get Worse
- Wear Red Today! It’s Women’s Heart Health Awareness Day
- Can Marijuana Ease NFL Players’ Pain? Claims Are All Over The Field
- Mid-Life Crisis Clusters Found In 4 US Cities
- Cambridge researcher develops smartphone app to map Swiss-German dialects
- Studies link healthy workforces to positive stock market performance
- Pioneering discovery leads to potential preventive treatment for sudden cardiac death
- Online shopping might not be as green as we thought
- Gene family turns cancer cells into aggressive stem cells that keep growing