Chikungunya virus has been terrorizing some parts of the world by causing disease in humans through Aedes albopictus mosquitoes.
They belong to a family called alpha virus. Virulence can be attributed to the glycoproteins, E1 and E2 which also line the shell of the virus. Glycoprotein E1 is responsible for membrane fusion and E2 ( a product of cleavage of p62 by Furin, E3 being the second product) is responsible for receptor recognition. p62 and E1 exist as a precursor before Furin cleaves p62 into E2 and E3.
In a recent Letter to Nature, James E. Voss et al solved the structure of p62-E2 complex as well as E1-E2-E3 complex. This structural insight will help us understand the nature of interaction between the virus and human cells at the level of receptor recognition and membrane fusion following endocytosis.Another interesting aspect is that a change in pH in the endosome transitions the precursor to the mature proteins and subsequently providing virulence.
The X-ray structure of this virus gives valuable insights about the three dimensional structure and therefore epitopes which could be targeted for the development of vaccines against the virus.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Researchers Created A Laser Bullet To See What It Would Look Like - And Here It Is
- What Americans Fear Most Isn't Ebola Or Terrorism, It's...
- Great Earthquakes Doubled In The Most Recent 10 Year Period - What That Means
- ECFA Workshop: Planning For The High Luminosity LHC
- Slavery In America: Back In The Headlines
- Why Climate 'Uncertainty' Is No Excuse For Doing Nothing
- Dams Are Not The Smart Way To Secure Water For Agriculture
- "Very interesting article. There is a fascinating new drug, PSCK9 inhibiter, currently under..."
- "Here is what surface station really have measured..."
- "You enjoy taking down comments you do not like, don't you king of strawman arguments? ..."
- "I'm sorry the definition was 'one who believes there is no diety' Though my point remains valid..."
- "Wasn't the Webster definition 'someone who believes there is no god' Wouldn't this only be applicable..."
- National Wildlife Refuge System bans on GMOs and neonics lack transparency, scientific rationale
- Want better sperm? Eat more pesticides
- Beyond universal donors, some people are programed with no blood type at all
- Anti-conventional ag movement spurs Big Ag to look to organic pesticides
- Can people really inherit memories?
- An end to fat shaming? The 50 year DNA mystery of metabolic dysfunction may soon be solved
- 100 days in Michigan: U-M team releases new analysis of state's Medicaid expansion
- Trans fats still weighing Americans down
- Can bariatric surgery lead to severe headache?
- Study examines readmission after colorectal cancer surgery as quality measure
- Online dermatologic follow-up for atopic dermatitis earns equivalent results