Researchers at the University of New South Wales (UNSW) believe that blood may hold vital insights into what is happening in the brain of patients with chronic fatigue syndrome (CFS).
In a study unparalleled in its scope, a team led by UNSW Professor Andrew Lloyd of the Centre for Infection and Inflammation Research, has studied the differences in gene expression patterns in the blood of people who either recover promptly after acute glandular fever or develop the prolonged illness called post-infective syndrome.
The researchers examined six million pieces of gene expression information for analysis in the project, known as the Dubbo Infection Outcomes Study. The study is named after the NSW town in which the work was conducted. The team studied the expression of 30,000 genes in the blood, testing each of the 15 individuals between four and five times over a 12-month period.
The team was able to narrow its findings to the expression of just 35 genes whose pattern of expression correlated closely with the key symptoms of the illness when examined from onset through to recovery. Gene expression is significant because it is the process by which a gene’s DNA sequence is converted into the proteins which ultimately determine the manifestations of disease.
The research paper has been published and selected for editorial comment in the prestigious Journal of Infectious Diseases.
Since 1999, the team has been tracking the long-term health of individuals infected with Ross River virus (RRV), Q fever infection and Epstein-Barr virus, which causes glandular fever.
“These  genes might point to the nature of the disease process that underlies CFS, which is currently unknown,” said Professor Lloyd, who is based in the School of Medical Sciences at UNSW. “None of them are ones that I would have predicted, except for those relating to neurotransmitters,” he concedes. “Some of them relate to transport of zinc and other metal ions within the cell, which may suggest a fundamental disturbance in cellular function.”
The researchers now hope to take narrow the focus of research onto the expression of these 35 genes in the blood of a much larger group of subjects from the Dubbo Infection Outcomes Study, with varied patterns of illness and recovery.
“There are very few complex diseases which have been comprehensively analysed, with large scale and longitudinal studies, like this,” said Professor Lloyd. “It sets a standard for highly sophisticated, comprehensive gene expression studies in the blood of all sorts of human diseases from rheumatoid arthritis and multiple sclerosis through to schizophrenia.”
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Thank You Guido
- VB-111 Gene Therapy Doubles Survival In Recurrent Glioblastoma
- 'Greenwashing' Perception Sullies Eco-Friendly Reputation
- Replacing Exercise With A Pill
- September 24th, 2015 - Just Another Day In Space - Asteroid Flybys, "Blood Moons" And Armageddon Demystified
- Online Market For Invasive Plants Is Booming
- Public Health vs. EU's Tobacco Product Directive: The Battle is Joined
- "I think the problem is in thinking of X as an exercise pill. As noted, exercise has a wide variety..."
- "Oh, are you talking about the numbers? The 24 hours with a set tilt of 23.44 degrees (which..."
- "Robert,'WHAT embitters the world is not excess of criticism, but absence of self-criticism.'and'So..."
- "Thanks Robert. I very much appreciate your reply. I read it carefully. It certainly would be classified..."
- "Hi Joe, I've been traveling and limited access because I left my keyboard behind and had to buy..."
- Stimulant meds safe, effective for children with ADHD and congenital heart disease
- Hotel 'greenwashing' dirties eco-friendly reputation
- Coincidence or conspiracy? Investigating if believers see so much secret design
- 'Greenwashing' actually dirties eco-friendly reputation
- Language about climate change differs between proponents and skeptics