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    Does The Ad-36 Virus Cause Obesity?
    By News Staff | August 21st 2007 09:26 AM | 5 comments | Print | E-mail | Track Comments
    97 million Americans are overweight or obese. Obesity is considered an epidemic these days. Could a virus be behind it?

    Scientists have presented a new study showing infection with the adenovirus-36 (Ad-36) virus, long recognized as a cause of respiratory and eye infections in humans, may be a contributing factor.

    Their laboratory experiments they showed that infection with Ad-36 transforms adult stem cells obtained from fat tissue into fat cells. Stem cells not exposed to the virus, in contrast, were unchanged.



    They obtained adult stem cells from fatty tissue from a broad cross-section of patients who had undergone liposuction. Half of the stem cells were exposed to Ad-36 and the other half were not exposed to the virus.

    After about a week of growth in tissue culture, most of the virus-infected adult stem cells developed into fat cells, whereas the non-infected stem cells did not, the researchers say.

    The research group recently identified a gene in the Ad-36 virus that appears to be involved in causing fat accumulation observed in infected animals. That gene, called E4Orfl, is now emerging as a promising target for future human therapies, such as vaccines and anti-viral medicines, aimed at preventing or inhibiting the obesity virus, she says.

    The exact mechanism by which the virus might cause obesity in people is currently unknown, says Magdalena Pasarica, M.D., Ph.D., of the Pennington Biomedical Research Center, a campus of the Louisiana State University system, who does not rule out the possibility that other human viruses may also contribute to obesity.

    Researchers also do not know how long the virus remains in the body of obese individuals nor how long its fat-enhancing effect lasts once the virus is gone. However, Pasarica notes a recent study demonstrated that animals that developed the virus remained obese up to six months after their infection was gone. More studies are needed, especially in humans, she adds.

    “We’re not saying that a virus is the only cause of obesity, but this study provides stronger evidence that some obesity cases may involve viral infections,” says Pasarica. “Not all infected people will develop obesity,” she notes. “We would ultimately like to identify the underlying factors that predispose some obese people to develop this virus and eventually find a way to treat it.”

    Pasarica was part of the original research group which demonstrated that the Ad-36 virus was capable of causing animals infected with the virus to accumulate fat. Led by Nikhil Dhurandhar, Ph.D., now an associate professor at Pennington Biomedical Research Center, the group also conducted a noted epidemiologic study — the first to associate a virus with human obesity — showing 30 percent of obese people were infected with the Ad-36 virus in comparison to 11 percent of lean individuals. But evidence that the virus could actually cause fat levels to increase in human cells was lacking until now, Pasarica says.

    Pasarica and her associates are now in the process of trying to identify the factors that predispose some people with the virus to develop obesity while others do not, but results of this investigation are not yet available, they say.

    Source: American Chemical Society, BIOHW 003, presented at 10:15 a.m., Monday, Aug. 20, at the Boston Convention & Exhibition Center, Room 203, during the symposium, “Genomics of Obesity.”

    Comments

    Would this virus be transmitted through meat? Might meat producers intoduce this to their animals to produce larger fatter animals collecting many more dollars? In fact I would suspect an agricultural biologist of producing it in the first place and if any animal meat is not cooked very well I suspect the virus is transmited. Please correct me if I'm wrong.

    Since domestic animals are infected with the AD-36 virus so they will be bigger and fatter do we become infected by eating it? All dairy products must be loaded with it. You we need to become vegans to avoid it?

    no you do not need to become a vegitarian to avoid obtaining the virus, like humans some animals are immune to the virus and are not affected at all.

    If you get infected by this virus, what can you do to cure it? Can you transmit this to your family? How can prevent from catching it?

    listen people even if there was something in this theory it would appear that ad-37 or any adenovirus for that matter cannot be a main cause for obesity in anyone.
    If i take anyone who has ad-37 and put him on a portion controlled healthy food lifestyle (not a diet as channel 4 suggested eating fruit was) and make him do 30 minutes intensive exercise plus 30 minutes at least low intensity exercise (walking) every day, they would lose weight remarkably quickly.
    Now It would appear that the study into ad-37 and obesity has been rather poor. There are no consideration for external factors other then the infection of ad-37. They don't even consider how much someone eats a day. the objective fact that if someone eats less and more healthily, and does regular exercise they will lose weight, seems to have slipped the scientists minds.
    Perfectly slim people do have the virus as well but it is not as prevalent as in fat people. Could be being fat , therefore, mean that you are much more likely to have the virus. Fat peoples' immune systems are a lot worse then thin people at preventing pathogens. The logical conclusion to my mind therefore is that ad-37 is contracted as a result of someone being fat and while it might have some effect on fat cells, regular exercise and a healthy eating pattern WILL mean a normal body size. It is time for people to stop making excuses!!!