Researchers have discovered the probable cause of several infectious agents at the same time. Paramyxoviruses originate from bats and from there the pathogens have spread to humans and other mammals. In total, the new study tested 9,278 animals for viruses, among them 86 species of bats and 33 rodent species, leading to the discovery of an enormous number of new virus species. This could make eradicating many dangerous diseases significantly more difficult than had been thought. For bats provide a reservoir from which viruses could come back after vaccination campaigns.
"We already knew from prior studies that bats and rodents play a role as carriers of paramyxoviruses," said Prof. Dr. Christian Drosten, Head of the Institute for Virology at the Universitätsklinikum Bonn. The many varied members of this large virus family cause, e.g., measles, mumps, pneumonias and colds. The highly dangerous Hendra and Nipah viruses cause types of encephalitis that result in death for one out of two patients. Paramyxoviruses also play a role in veterinary medicine, causing e.g., canine distemper or rinderpest.
With support from numerous scientific institutes in Germany and around the world, researchers tested a total of 9,278 animals from Europe, South America and Asia, including 86 bat and 33 rodent species. "These animals live in very large social communities with millions of individuals in some cases. Their close contact promotes mutual infection and provides for great variety in circulating viruses." Using molecular biology methods, the scientists identified which virus species are rampant in bats and rodents. According to their own estimates, they discovered more than 60 new paramyxovirus species. "That is about as many as the number that was already known," said Drosten.
Bats are the original paramyxovirus hosts
Using computational biology methods, the scientists calculated a common evolutionary tree for the new and the known viruses. They then deduced, using mathematical methods, in which host animals the viruses have most likely taken up residence during their evolutionary history. "Our analysis shows that almost all of the forebears of today's paramyxoviruses have existed in bats," explained Prof. Drosten. "Just as with influenza, where we are keeping an eye on birds as a source of new pandemic viruses, we will now have to study the bat viruses to see if they are a danger to humans." So, the current data might play a useful role in early detection and prevention of epidemics – a major new goal in virus research.
Bats are the original paramyxovirus hosts. Credit: Florian Gloza-Rausch/Uni Bonn/Noctalis Bad Segeberg
Mumps viruses have jumped to humans
The findings also included that the Hendra and Nipah viruses that cause encephalitis in Asia and Australia really came from Africa. "This results in an urgent need to conduct medical studies in Africa," said the Bonn virologist, adding that many disease cases on this continent remain unexplained and might possibly have been caused by such new viruses. In one case, the scientists have already found proof that bat viruses transfer directly to humans. "Our data show that the human mumps virus comes directly from bats – and can be found there to this day," reported Drosten.
These results indicate that it may not be as easy to eradicate dangerous viruses as had been assumed. For eliminating an infectious agent permanently from the population by means of vaccination requires that there are no animal hosts from which a new infection might come. "In bats, we assume that there is a vast reservoir of such agents," said Drosten. "If the vaccination campaigns are stopped once a virus has been eradicated, this might present a potential risk - maybe we will have to rethink." This is why he advocates taking into account ecological data when planning vaccination campaigns. Eradicating bats or other wild animals would be neither possible nor sensible. "Bats and other small wild mammals are of immeasurable value for our planet's ecosystems."
Citation: "Bats host major mammalian paramyxoviruses", Nature Communications, DOI: 10.1038/ncomms1796
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Bang !! 13 TeV - The Highest Energy Ever Achieved By Mankind ?!
- Mystery Of Morgellons - Disease Or Delusion - Scientific Hypothesis Of Connection With Lyme Disease
- WISE J224607.57-052635.0, The Most Luminous Galaxy In The Universe
- Highest Energy Collisions ? Not In My Book
- Blue Buffalo Admits Its Pet Food Contains The Poultry Byproduct It Ridicules In Competitors
- Tanzania's Disappearing Serengeti
- NaSt1 - One-Of-A-Kind 'Nasty' Star
- "Okay for what she says about BDD, see her paper here: Association of spirochetal infection..."
- "Bovine Digital Dermatitis was connected to morgellons disease because of wart-like and hair-like..."
- "FINALLY, a supportive article that reviews the facts and is not afraid to put it out in a positive..."
- "Thank you for your wonderful article. It is refreshing to see someone write about this disease..."
- "Dear all,thank you for your thoughts. As it often happens, the global common knowledge of a pool..."
- Vaccines developed for H5N1, H7N9 avian influenza strains
- European Medicines Agency recommends full approval of ibrutinib to treat Waldenstrom's Macroglobulinemia
- In Northern Ireland, sectarianism has become sextarianism
- RegeneRx Phase II Dry Eye Trial results
- How schizophrenia risk gene DISC1 affects the brain