Results presented at the 2014 World Transplant Congress evaluated the safety and efficacy of CSL Behring's C1 Inhibitor (C1-INH) concentrate in preventing antibody-mediated rejection following kidney transplants in highly sensitized patients.
C1-INH is a human protein and an important inhibitor of the complement system. Antibody-mediated rejection is a major cause of kidney transplant failure and a prime barrier to improving long-term outcomes for transplant patients. The types of antibody-mediated rejection vary in acuity and severity. Approximately 10 to 15 percent of kidney recipients experience rejection within one year after transplantation.
The placebo-controlled, single-center study evaluated 20 highly sensitized patients, meaning they already had antibodies against donor organs. Subjects were randomized to receive either placebo or 20 IU/kg of C1-INH, administered intra-operatively, then twice a week for seven additional doses. Patients were desensitized with immunoglobulin and rituximab, decreasing the patient's antibody levels prior to transplant.
The study found that post-transplant treatment with C1-INH results in significant increases in the levels of complement components 3 and 4, suggesting that C1-INH inhibits activation of the complement system following transplantation. Antibody-mediated rejection is a major cause of kidney transplant failure and is often associated with activation of complement, a set of proteins that work with antibodies and play a role in the development of inflammation and tissue damage.
According to study findings, fewer patients who were administered C1-INH developed serious adverse events compared to those administered placebo (20 percent versus 30 percent). C1-INH function and antigen levels in blood increased with C1-INH treatment [C1 function (p=0.0007) and C1-INH antigen percent (p=0.013)]. Patients treated with C1-INH experienced increased C3 levels on day 30 (p=0.005), while C4 levels were significantly higher at all time points.
During the study period, no patient treated with C1-INH developed antibody-mediated rejection. Twenty percent of patients developed antibody-mediated rejection following the study period. Thirty percent of patients treated with placebo developed antibody-mediated rejection, ten percent during the study period.
"Antibody-mediated rejection is a severe form of rejection that can occur in patients who have undergone a kidney transplant," said Stanley C. Jordan, M.D., Kidney Transplant, Cedars-Sinai Medical Center in Los Angeles, and one of the study's investigators. "Our findings provide additional insight into how C1-INH affects complement activation and represent an important advance in the study of complement-targeting therapeutics."
This Investigator-Initiated Research study was supported by CSL Behring.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- My Applied National Security Paper. Being President Isn't For Idiots.
- Why An Extra Planet Can't Be Hidden Behind The Sun Or Above The South Pole
- Hugh Hefner's Wife Was Not Poisoned By Breast Implants
- Watering Solar Cells Makes Them Grow ... In Power!
- Why Has Organic Farming Flatlined?
- Top Scientists Chastise Greenpeace
- I am Sorry Retractions and First Ever Book Recommendation
- "If something was about to hit us how will we find out before ..."
- "You have a point. I grew up on an organic farm long before those were cool - it was called being..."
- "The same argument applies to all and any possible dates. Ask them which constellation it is in..."
- "No, because the whole thing is smoke and mirrors, it's impossible. If anyone says there's a planet..."
- Opercular index score: A novel approach for determining clinical outcomes in stroke
- Cataclysm at Meteor Crater: Crystal sheds light on Earth, moon, Mars
- Workforce processes prior to mechanical thrombectomy vary widely, new study finds
- Male frogs have sex on land to keep competitors away
- Cord blood outperforms matched, unrelated donor in bone marrow transplant