The Genome Question - What Do We Have In Common With A Gorilla?
    By News Staff | March 7th 2012 07:48 PM | 4 comments | Print | E-mail | Track Comments

    Researchers have completed the genome sequence for the gorilla, the last genus of the living great apes to have its genome decoded. The results confirm that our closest relative is the chimpanzee but much of the human genome more closely resembles the gorilla than it does the chimpanzee genome.

    For the first time, scientists can compare the genomes of all four living great apes: humans, chimpanzees, gorillas and orangutans. This provides a unique perspective on our own origins and is an important resource for research into human evolution and biology, as well as for gorilla biology and conservation.  

    The team searched more than 11,000 genes in human, chimpanzee and gorilla for genetic changes important in evolution. Humans and chimpanzees are genetically closest to each other over most of the genome, but the team found many places where this is not the case. 15% of the human genome is closer to the gorilla genome than it is to chimpanzee, and 15% of the chimpanzee genome is closer to the gorilla than human.

    In all three species, genes relating to sensory perception, hearing and brain development showed accelerated evolution – and particularly so in humans and gorillas.

    "The gorilla genome is important because it sheds light on the time when our ancestors diverged from our closest evolutionary cousins. It also lets us explore the similarities and differences between our genes and those of gorilla, the largest living primate," says Aylwyn Scally, first author from the Wellcome Trust Sanger Institute. "Using DNA from Kamilah, a female western lowland gorilla, we assembled a gorilla genome sequence and compared it with the genomes of the other great apes. We also sampled DNA sequences from other gorillas in order to explore genetic differences between gorilla species."

    This research also illuminates the timing of splits between species. Although we commonly think of species diverging at a single point in time, this does not always reflect reality: species can separate over an extended period of time.

    The team found that divergence of gorillas from humans and chimpanzees occurred around ten million years ago. The split between eastern and western gorillas was much more recent, in the last million years or so, and was gradual, although they are now genetically distinct. This split is comparable in some ways to the split between chimpanzees and bonobos, or modern humans and Neanderthals.

    "Our most significant findings reveal not only differences between the species reflecting millions of years of evolutionary divergence, but also similarities in parallel changes over time since their common ancestor," says Dr Chris Tyler-Smith, senior author from the Wellcome Trust Sanger Institute. "We found that gorillas share many parallel genetic changes with humans including the evolution of our hearing. Scientists had suggested that the rapid evolution of human hearing genes was linked to the evolution of language. Our results cast doubt on this, as hearing genes have evolved in gorillas at a similar rate to those in humans."

    Gorillas survive today in just a few isolated and endangered populations in the equatorial forests of central Africa. They are severely threatened and their numbers are diminishing. This research not only informs us about human evolution, but highlights the importance of protecting and conserving the full diversity of these remarkable species.

    "Our research completes the genetic picture for overall comparisons of the great apes," says Dr Richard Durbin, senior author from the Wellcome Trust Sanger Institute, "After decades of debate, our genetic interpretations are now consistent with the fossil record and provide a way for palaeontologists and geneticists to work within the same framework. Our data are the last genetic piece we can gather for this puzzle: there are no other living great ape genera to study."


    The questioned posed on the BBC newscast of this story, questioned once again, at what point we were evolutionarily separated from apes. Isn't it obvious? The ability to speak, then communicate... and to question, analyze... based on the information communicated allowed a geometric learining curve not possible to those who species who were unable to communicate clearly! This is not difficuly. Ask Helen Keller.

    Tony Fleming
    What does 'accelerated evolution' mean in genetic terms? I'm referring to the 'mystery skulls of Palau' (National Geographic) where it seems an accelerated evolution led to changes over the course of a few thousand years. The line of reason being that these humans must have sailed to Palau after the advent of sailing craft to get to the islands. What sort of time are we refering to in this case? Any one know? cheers Tony
    Tony Fleming Biophotonics Research Institute
    How much more do we need to know before we let these sad gorillas out of the zoos? Chimpanzees as well. It's inhumane and we all know it at heart.

    I find any work on primates absolutely intrigueing. Some work that i have recently seen in this area is the work of Jeremy Griffith an Australian biologist. He has just written an article about biology and science, I suggest anybody interested in science would find it facinating