New research published in Stroke has linked the risk of suffering a stroke to the presence of a certain type of antibody in the immune system. According to the study, researchers may now be able to develop a vaccine that can mobilize the body's own defence against arteriosclerosis and stroke.
The study compared 227 individuals who had suffered stroke over a 13-year period with 445 sex and age-matched controls. After controlling for other risk factors (age, sex, smoking habits, cholesterol levels, diabetes, BMI and blood pressure), they were able to show that low levels (below 30 per cent of average) of PC antibodies correlated with a higher risk of stroke, which in women meant an almost three-fold increase.
The researchers have now advanced the hypothesis that low levels of natural PC antibodies, which can be a condition of a poor immune system – contribute to the development of arteriosclerosis and its consequences, which include stroke.
"We're now examining the possibility of developing new immunological treatments for arteriosclerosis and stroke, either in the form of a vaccine to stimulate the immune defence or immunisation through the injection of antibodies," says co-author Professor Johan Frostegård of the Karolinska Institutet.
Citation: Fiskesund et al., 'Low levels of antibodies against phosphorylcholine predict development of stroke in a population based study from Northern Sweden', Stroke, February 2010; doi: 10.1161/STROKEAHA.109.558742
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part II: Bee Deaths And CCD - Flawed Chensheng Lu Harvard Studies Endanger Bees
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Surveys Show Global Warming Belief Doesn't Change With The Weather
- The BPA Paradox – Too Many Studies?
- Reasons Serious Scientists Should Not Fear The Winnower and other OA Open Review Journals.
- Education: Stop New Age Thinking, Chalk And Talk Might Be The Best Way After All
- Big Data Could Be A Big Problem For Workplace Discrimination Law
- "Where's the beef?..."
- "Your statement is outrageous. What mistake have I made? Please elaborate. The scientists quoted..."
- "I think that is due to the Winnower being in Beta. ..."
- "Jon, I think that with all due respect you have made a serious mistake with this article which..."
- "I am a leftist. I am for a revenue-nuetral carbon tax. Having the CO2 externalities part of the..."
- Lancet article: Afferent's P2X3 inhibitor shows 75 percent reduction in chronic cough frequency
- News from Annals of Internal Medicine Supplement
- Boy moms more social in chimpanzees
- Unmanned underwater vehicle provides first 3-D images of underside of Antarctic sea ice
- CT scans of coral skeletons reveal ocean acidity increases reef erosion