Researchers have discovered a way to stimulate the brain's natural defense mechanisms in people with Alzheimer's disease. 

One of the main characteristics of Alzheimer's disease is the production in the brain of the toxic molecule amyloid beta. Microglial cells, the nervous system's defenders, are unable to eliminate this substance, which forms deposits called senile plaques. 

A team has found that the molecule known as MPL (monophosphoryl lipid A) stimulates the activity of the brain's immune cells. MPL has been used extensively as a vaccine adjuvant by GlaxoSmithKline for many years, and its safety is well established. In mice with Alzheimer's symptoms, weekly injections of MPL over a twelve-week period eliminated up to 80% of senile plaques. In addition, tests measuring the mice's ability to learn new tasks showed significant improvement in cognitive function over the same period.

The researchers see two potential uses for MPL. It could be administered by intramuscular injection to people with Alzheimer's disease to slow the progression of the illness. It could also be incorporated into a vaccine designed to stimulate the production of antibodies against amyloid beta. "The vaccine could be given to people who already have the disease to stimulate their natural immunity," said Dr. Serge Rivest, professor at Université Laval's Faculty of Medicine. "It could also be administered as a preventive measure to people with risk factors for Alzheimer's disease."

"When our team started working on Alzheimer's disease a decade ago, our goal was to develop better treatment for Alzheimer's patients," explained Rivest, also researcher at the CHU de Québec research center. "With the discovery announced today, I think we're close to our objective."


Published in the Proceedings of the National Academy of Sciences (PNAS)