RXi Pharmaceuticals Corporation, an RNA-targeted technologies company, today announced positive results from their second placebo-controlled Phase 1 study with RXI‑109, an sd-rxRNA compound that targets Connective Tissue Growth Factor (CTGF), and is being developed for the treatment of abnormal dermal scars such as hypertrophic scars and keloids in conjunction with scar revision surgery.
In this study, subjects received small skin incisions in their abdomen and were treated with 3 intradermal doses of RXI‑109 over a 2-week period. This dose escalating study consisted of 3 cohorts of 3 healthy volunteers each. Subjects received RXI‑109 on one side of the abdomen, and placebo on the other side.
Subjects were monitored for safety and local and systemic side effects over a total study period of 84 days.
Multiple dermal injections were well tolerated at all doses and treatment with RXI‑109 resulted in dose-dependent silencing of CTGF mRNA in the treated areas.
Dr. Geert Cauwenbergh, President and CEO of RXi Pharmaceuticals said that, "We are very pleased with the outcome of this second Phase 1 study. These results show that multiple intradermal injections of RXI‑109 are well tolerated with minimal and mild side effects. He added that, "The work done in the last year has confirmed that our proprietary self-delivering RNAi technology (sd-rxRNA) reduces CTGF mRNA in humans in line with its mechanism of action. Indeed, results from this second study demonstrate that mRNA for CTGF in the incisions is reduced in a dose-dependent manner by RXI‑109 as compared to placebo. Our first Phase 1 study had already shown that a single dose of the drug lowered the actual protein content for CTGF also in a dose-dependent manner. With this exciting outcome, we are ready to embark on Phase 2 development in patients with hypertrophic scars and keloids."
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Schrödinger's Cat Is Not Just Alive And Dead, He's Both In 2 Places At Once
- B0 Meson Lifetime Difference Measured By ATLAS
- Energy Consumption Will Increase 48% By 2040, Led By Countries Exempt From Climate Treaties
- Case For Moon: Humanity's Gateway To The Solar System - Open Ended Exploration With Planetary Protection At Its Heart
- Sweet Irony: The Environmental Impacts Of GMO Sugar Science Denial
- The Politics Of Antibiotic Resistance Factor MCR
- Italian Food Scientists Are Tired Of Phony Cheese
- "Milk is so tasty. Soy, Oy! CO2 is fertilizer for plants. We need more of it. Meat is tasty too..."
- "Both the Pacific Salmon Forum and the Cohen Commission agree there is scant evidence farming salmon..."
- "If interested in an electromagnetic model of the photon structure and its absorption process, as..."
- "I agree with you in theory, but in the case of this particular salmon, I do not think it will turn..."
- "Homeopathy is based on the ‘like cures like’ principle: if a substance causes a set of symptoms..."
- The Name Game: How Unethical Environmental Groups and Toxic Fanatics Scare You With Words
- Naturopathy: A Pre-holiday Rant
- Misdiagnosis of Dehydration in Older Folks
- The Amazing Things Poo Can Tell Us About Health
- This Dinner Plate Sucks—Literally
- Gwynn’s Appeal to Jury Could Overshadow Medical Science
- New meta-analysis shows ketamine effective against persistent post-surgical pain and could provide major cost-savings globally
- Refusing access to surgery recovery area at a UK hospital unless WHO Safe Surgery Checklist is fully complete
- Investment in energy storage vital if renewables to achieve full potential
- The Lancet Oncology: Teenagers and young adults still fare worse than children for many common cancers, according to Europe-wide
- Coping with active surveillance anxiety in prostate cancer