Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.
"Recently, changes in gene programming due to a chemical transformation called methylation have been found in the blood and tissues of lung cancer patients," said investigator Andrea Baccarelli, M.D., Ph.D., assistant professor of applied biotechnology at the University of Milan. "We aimed at investigating whether exposure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to high levels of particulate matter in a foundry facility."
Researchers enrolled 63 healthy subjects who worked in a foundry near Milan, Italy. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor suppression.
"The changes were detectable after only three days of exposure to particulate matter, indicating that environmental factors need little time to cause gene reprogramming which is potentially associated with disease outcomes," Baccarelli said.
"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," he added. "The changes in DNA methylation we observed are reversible and some of them are currently being used as targets of cancer drugs."
Baccarelli said the study results indicate that early interventions might be designed which would reverse gene programming to normal levels, reducing the health risks of exposure.
"We need to evaluate how the changes in gene reprogramming we observed are related to cancer risk," he said. "Down the road, it will be particularly important not only to show that these changes are associated with increased risk of cancer or other environmentally-induced diseases, but that, if we were able to prevent or revert them, these risks could be eliminated."
The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego.
Session # A45: "Genetic Basis for Environmental and Occupational Respiratory Diseases"
Abstract # 2589: "Effects of Particulate Matter Exposure on p16, p53, APC and RASSF1A Promoter Methylation"
Poster Board # C51
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Wait, Let's Not Be In Such A Rush To Go Multiplanetary Or Interstellar - A Comment On Elon Musk's Vision
- Study Explains Mechanisms Behind Glioblastoma Influence On The Immune System
- New Score Seeks To Expand Pool Of Kidneys Available For Transplant
- Chatelperronian Hominins: Disputed Neanderthal Region Confirmed In France
- Paleo: In A Clinical Trial, Bread Made With Ancient Grains Could Benefit Heart Health
- Ground Squirrels Use The Sun To Hide Food
- Molecular Atlas Of The Pancreas Produced
- "Oh, had to look it up, that's the first asteroid to be detected with a tiny 1 in a million chance..."
- "Robert hey you know the asteroid called 2002 NT7? I know that NASA already ruled out the possibility..."
- "Seems you agree with me a few things. How would you make your own scale? (ignoring desire for the..."
- "Well, first there's the timescale. If you build a dyson sphere, you don't have the capability to..."
- "I don't think that much of the Kardashev scale. Especially L2,3 star vs galaxy. How would it be..."
- Is Parenting Kids of Human and Canine Persuasion the Same? Yes!
- Diabetes: MiniMed 670G Hybrid Closed-Loop Insulin System Is A Waypoint To An Artificial Pancreas
- Celebrate Oktoberfest with Beer Chemistry
- Littlest Consumers Doing Well, Nutrition-wise
- Herpes Vaccine Update: Exciting News, But Don't Throw Away Condoms Just Yet
- Ben & Jerry’s Asks Us to Take Big Lick of Fear & Hype
- How would you like a kitchen surface that cleans itself?
- Vitamin D could help control TB in animals
- Antipsychotic medications linked to increased risk of pneumonia in persons with Alzheimer's disease
- Multiple sclerosis misdiagnosis shows need for improved education of clinicians
- Brown adipose tissue can secrete factors that activate fat and carbohydrate metabolism