Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.
"Recently, changes in gene programming due to a chemical transformation called methylation have been found in the blood and tissues of lung cancer patients," said investigator Andrea Baccarelli, M.D., Ph.D., assistant professor of applied biotechnology at the University of Milan. "We aimed at investigating whether exposure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to high levels of particulate matter in a foundry facility."
Researchers enrolled 63 healthy subjects who worked in a foundry near Milan, Italy. Blood DNA samples were collected on the morning of the first day of the work week, and again after three days of work. Comparing these samples revealed that significant changes had occurred in four genes associated with tumor suppression.
"The changes were detectable after only three days of exposure to particulate matter, indicating that environmental factors need little time to cause gene reprogramming which is potentially associated with disease outcomes," Baccarelli said.
"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," he added. "The changes in DNA methylation we observed are reversible and some of them are currently being used as targets of cancer drugs."
Baccarelli said the study results indicate that early interventions might be designed which would reverse gene programming to normal levels, reducing the health risks of exposure.
"We need to evaluate how the changes in gene reprogramming we observed are related to cancer risk," he said. "Down the road, it will be particularly important not only to show that these changes are associated with increased risk of cancer or other environmentally-induced diseases, but that, if we were able to prevent or revert them, these risks could be eliminated."
The research will be presented on Sunday, May 17, at the 105th International Conference of the American Thoracic Society in San Diego.
Session # A45: "Genetic Basis for Environmental and Occupational Respiratory Diseases"
Abstract # 2589: "Effects of Particulate Matter Exposure on p16, p53, APC and RASSF1A Promoter Methylation"
Poster Board # C51
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Schrödinger's Cat Is Not Just Alive And Dead, He's Both In 2 Places At Once
- Case For Moon: Humanity's Gateway To The Solar System - Open Ended Exploration With Planetary Protection At Its Heart
- Mindfulness Is Not A Waste Of Time
- B0 Meson Lifetime Difference Measured By ATLAS
- Voluntary Birth Control To Stop Climate Change - Or Else
- Arctic Ocean Methane Does Not Reach The Atmosphere
- Why Malnutrition Is An Immune Disorder
- "this must be mystery, Cat Mystery. lol..."
- "Vampire are not real, and can never be. This stuff is limited to movies only...."
- "Milk is so tasty. Soy, Oy! CO2 is fertilizer for plants. We need more of it. Meat is tasty too..."
- "Both the Pacific Salmon Forum and the Cohen Commission agree there is scant evidence farming salmon..."
- "If interested in an electromagnetic model of the photon structure and its absorption process, as..."
- The Name Game: How Unethical Environmental Groups and Toxic Fanatics Scare You With Words
- Naturopathy: A Pre-holiday Rant
- Misdiagnosis of Dehydration in Older Folks
- The Amazing Things Poo Can Tell Us About Health
- This Dinner Plate Sucks—Literally
- Gwynn’s Appeal to Jury Could Overshadow Medical Science
- New meta-analysis shows ketamine effective against persistent post-surgical pain and could provide major cost-savings globally
- Refusing access to surgery recovery area at a UK hospital unless WHO Safe Surgery Checklist is fully complete
- Investment in energy storage vital if renewables to achieve full potential
- The Lancet Oncology: Teenagers and young adults still fare worse than children for many common cancers, according to Europe-wide
- Coping with active surveillance anxiety in prostate cancer
About Us |