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    Wound Dressings Work: Review Finds That, In Skin Ulcers, Alternative Methods Are Unreliable
    By News Staff | December 27th 2013 06:00 AM | Print | E-mail | Track Comments

    A systematic review of 66 research papers focused on the treatment of skin ulcers suggests that most are so technically flawed that their results are unreliable, and even of those that aren't flawed only weak evidence that alternative treatments work better than standard compression therapy or special stockings. 


    Chronic wounds are a global problem. In addition to obesity and diabetes worldwide, skin ulcers occur as a consequence of neurological problems, rheumatological illnesses, blood vessel inflammation and infection. Non-healing wounds cause not only pain, but also loss of mobility and a general decline in physical and emotional well-being. Patients can become disabled, unable to work and dependent on care from others. 

    The research review team note than an estimated $25 billion is spent annually in the United States treating chronic skin wounds related mostly to poor blood circulation, disorders known as venous ulcers. Their prevalence is rising along with rates of diabetes and obesity, and the review was undertaken in an effort to inform physicians about the treatment options. 

    The review team, led by Gerald Lazarus, M.D., founder of the Johns Hopkins Wound Healing Center, and Jonathan Zenilman, M.D., scientific director of the Wound Healing Center, began by identifying 10,066 citations that were possibly related to wound care. They found that only 66 of these papers specifically addressed their questions about the effectiveness of treatments for chronic venous leg ulcers. 

    For the study, the investigators analyzed clinical outcomes involving wound dressings, antibiotics and venous surgery.

    Overall results found that dressings that used living human cells increased wound healing. Results suggested that cadexomer iodine and collagen may also increase healing, says Lazarus. "That doesn't mean that other types of dressings don't work. It just means that there is no evidence yet on which treatments work the best," says Lazarus. Support stockings, he adds, must for now remain the standard of care for treating chronic venous ulcers.

    Lazarus says the review also showed evidence is inconclusive about using systemic antibiotics unless there are demonstrated signs of infection. And it is also inconclusive about such surgical treatments as radiofrequency ablation, endovenous laser treatment and sclerotherapy helped healing, although surgical correction of underlying pathology did decrease recurrence of ulcers.

    "There is a critical need for well-designed research studies to compare the current minimally invasive surgical interventions to the gold standard of care, compression therapy," he says.