Inhibiting the action of a particular enzyme called polymerase theta, or PolQ, dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to a new paper. 

In the two decades existence of lab-on-a-chip (LOC), there have been lots of individual systems developed, ranging from lung-on-a-chip and heart-on-a-chip to the liver-on-a-chip and kidney-on-a-chip - but an ideal embryo-on-a-chip has eluded science because of the challenges in condensing so many life factors inside a conventional LOC. 

But now two scientists have developed a PDMS (polydimethylsiloxane) "soft" process method to fabricate a transparent shell matching the shape and curvature of a real eggshell.

The most important feature of a conventional "Lab-on-a-chip" is its chemically based character, or its scaling down chemical tests into a miniature-size device.

Naturally occurring arsenic in private wells threatens people in many U.S. states and parts of Canada, according to a package of a dozen scientific papers to be published next week. The studies, focused mainly on New England but applicable elsewhere, say private wells present continuing risks due to almost nonexistent regulation in most states, homeowner inaction and inadequate mitigation measures. The reports also shed new light on the geologic mechanisms behind the contamination. The studies come amid new evidence that even low doses of arsenic may reduce IQ in children, in addition to well documented risks of heart disease, cancer and reduced lung function. The reports comprise a special section in the journal Science of the Total Environment.

New research could lead to a better understanding of how the brain works in people with autism. Little is known about the cognitive processes involved.

Researchers from Monash University and Deakin University looked at new hypotheses of autism that focused on the way in which the brain combines new information from its senses with prior knowledge about the environment. Using the 'rubber-hand' illusion, the researchers examined how adults with autism experienced 'ownership' of a fake prosthetic hand.

In the 'rubber-hand' illusion, one of the subject's hands is placed out of sight, while a rubber hand sits in front of them. By stroking the fake hand at the same time as the visible real one, the subject can be convinced the fake hand is theirs.

The discovery of the first gene causing familial scoliosis was announced by an international France-Canada research team today. "Mystery surrounds the cause of scoliosis, which is a three dimensional deformation of the vertebral column. Many researchers have been attempting to uncover the origins of this disease, particularly from a genetic point of view," explained leading co-author Dr Florina Moldovan of the University of Montreal and the CHU Sainte Justine research hospital. "To date, many genes have been suspected of causing scoliosis amongst different populations, but the gene that causes the familial form of the disease remained unknown.

One saved the U.S. space program, another invented a better treatment for leprosy and a third spawned an industry in the American Midwest - but you have probably never heard of these female "legends of chemistry".

Their names are Mary Sherman Morgan, Alice Ball and Rachel Lloyd and they all had amazing accomplishments in chemistry, but their work was nearly lost to history.


Mary Sherman Morgan, Alice Ball and Rachel Lloyd. Credit: The American Chemical Society

This week ACS Reactions shines the spotlight on them so they can get some proper acclaim: