UK doctors subject to complaints procedures are at significant risk of becoming severely depressed and suicidal, reveals research published in the online journal BMJ Open.

Those referred to the UK professional regulator, the General Medical Council, seem to be most at risk of mental ill health, the findings suggest.

The researchers base their findings on an anonymised online survey of more than 95,000 UK doctors in 2012, all of whom were members of the British Medical Association (BMA).

Emerging data on the role of inflammation and the immune system in the development, growth, and spread of breast tumors have focused increased attention on the role cytokines such as interleukin and transforming growth factor-β play in breast cancer initiation, protection, and metastasis.

A comprehensive overview of this new knowledge and its potential to lead to novel therapeutic approaches is presented in a Review article in Journal of Interferon & Cytokine Research.

Researchers have created a new approach that protects animal models against a type of genetic disruption that causes intellectual disability, including serious memory impairments and altered anxiety levels. 

The method focuses on treating the effects of mutations to a gene known as Syngap1. Damaging mutations in Syngap1 that reduce the number of functional proteins are one of the most common causes of sporadic intellectual disability and are associated with schizophrenia and autism spectrum disorder.

Inflammation has long a target in Alzheimer's disease studies so a new finding in Neuron is counterintuitive. In the study, researchers hace uncovered the mechanism by which anti-inflammatory processes may trigger the disease and this anti-inflammatory process might actually trigger the build-up of sticky clumps of protein that form plaques in the brain. These plaques block brain cells' ability to communicate and are a well-known characteristic of the illness.

The finding suggests that Alzheimer's treatments might need to be tailored to patients depending on which forms of Apolipoprotein E, a major risk factor for Alzheimer's disease, these patients carry in their genes.

Bacteria communicate using chemical signals and now scientists have described a previously unknown communication pathway that appears to be widely distributed - and even leads to pathogens.

The investigation of bacterial communication is valuable because those pathways are a possible therapeutic target for new medicines. If the relevant communication options are prevented, the bacteria cannot develop their pathogenic properties.

Jupiter's moons are giving us a show not seen since 2013: The orbital path of the moons is tilting edge-ion to the Earth and the sun, making it possible to watch the moons pass in front of each other, an occultation, or pass through another moon's shadow, an eclipse, and even cast tiny black shadows onto Jupiter.