ANN ARBOR, Mich. — Blood transfusions are one of the most common procedures patients receive in the hospital but the more red blood cells they receive, the greater their risk of infection, says a new study led by the University of Michigan Heath System and VA Ann Arbor Healthcare System.

Researchers analyzed 21 randomized controlled trials for the study that appears in today's Journal of the American Medical Association (JAMA).

Elderly patients undergoing hip or knee surgeries were most susceptible, with a 30 percent lower risk of infection when fewer transfusions were used. Overall, for every 38 hospitalized patients considered for a red blood cell transfusion (RBC), one patient would be spared a serious infection if fewer transfusions were used.

DURHAM, N.C. -- Childhood obesity comes with an estimated price tag of $19,000 per child when comparing lifetime medical costs to those of a normal weight child, according to an analysis led by researchers at the Duke Global Health Institute and Duke-NUS Graduate Medical School in Singapore. When multiplied by the number of obese 10-year-olds in the United States, lifetime medical costs for this age alone reach roughly $14 billion.

An alternative estimate, which takes into account the possibility of normal weight children gaining weight in adulthood, reduces the cost to $12,900 per obese child. The findings appear online April 7, 2014, in the journal Pediatrics.

Endurance sport does not only change the condition and fitness of muscles but also simultaneously improves the neuronal connections to the muscle fibers based on a muscle-induced feedback. This link has been discovered by a research group at the Biozentrum of the University of Basel. The group was also able to induce the same effect through raising the protein concentration of PGC1α in the muscle. Their findings, which are also interesting in regard to muscle and nerve disorders such as muscle wasting and ALS, have been published in the current issue of the journal Nature Communications.

The dose makes the poison, it is often said. And that can be the case even with beneficial products like Acetaminophen.

Acetaminophen is a commonly used pain reliever that is available in over-the-counter products (Tylenol®) and prescription medications, where it is combined with opioid analgesics (i.e., fixed-dose combination products).  For example, acetaminophen in combination with the opioid hydrocodone (Vicodin^® and its generic formulations) was the most prescribed medication in the U.S. each year from 2007 through 2011, according to a report by the IMS Institute of Healthcare Informatics.¹ 

Evidence collected over a period of 16 years by NASA's Rossi X-ray Timing Explorer, a satellite in low-earth orbit equipped with instruments that measured variations in X-ray sources, has led to a paper in the Monthly Notices of the Royal Astronomical Society showing huge clouds of gas orbiting supermassive black holes at the centers of galaxies.

Picture a single cloud large enough to span the solar system from the sun to beyond Pluto's orbit. Now imagine many such clouds orbiting in a vast ring at the heart of a distant galaxy, occasionally dimming the X-ray light produced by the galaxy's monster black hole.

Arid areas are among the biggest (non-ocean) ecosystems we have and it turns out they take up higher levels of carbon as levels of carbon dioxide increase in the atmosphere.

The findings give scientists a better idea of the earth's "carbon budget" — how much carbon remains in the atmosphere as CO₂ and is a concern for global warming and how much actually gets stored in the land or ocean in other carbon-containing forms.