There are many objects in nature, such as flowers, that are “pre-programmed” to develop into delicate, beautiful and intrically shaped forms. But can this pre-determined process be duplicated by man starting with plain, flat surfaces?

Yes, say Dr. Eran Sharon and his co-workers, Yael Klein and Efi Efrati, at the Hebrew University of Jerusalem Racah Institute of Physics, who have succeded for the first time anywhere in programming polymer sheets to bend and wrinkle by themselves into prescribed structures. Their work was described in the journal Science.

They made flat discs of a soft gel that, when warmed gently, curved into domes, saddles and even sombrero shapes.

“It’s an amazing little marvel,” said Heinrich Jaeger, Professor in Physics at the University of Chicago. “This is not a very fragile layer, but rather a robust, resilient membrane.”

Even when suspended over a tiny hole and poked with an ultrafine tip, the membrane boasts the equivalent strength of an ultrathin sheet of plexiglass that maintains its structural integrity at relatively high temperatures.

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smoker’s high?

As with other questions involving good sensations, the answer appears to be sugar. A University of Southern California study proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotine’s arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it “a landmark accomplishment for the fields of structural biology and neuronal cell signaling.”

The driving forces behind major shifts in recent human evolution and adaptation have been the subject of intense debate for more than 100 years.

Should adolescents with depression be prescribed antidepressants, and if so, should they be given only with a psychological therapy, as advocated by the National Institute for Health and Clinical Excellence (NICE)?

A study published on bmj.com last month found that adding cognitive behaviour therapy (CBT) to selective serotonin reuptake inhibitor (SSRI) treatment is unlikely to improve outcomes for adolescents with moderate to severe depression.

These findings challenge current NICE guidelines that recommend SSRIs be prescribed only in conjunction with psychological therapies.

Simple nucleotide polymorphisms (SNPs), are single variations affecting only one nucleotide or base of the genomic sequence. Despite humans sharing 99.9% of the genome sequence, there are still 3 million genetic variations –which make us different from one another– 90% of which are due to SNPs.

An international collaboration has performed a large-scale study on genetic differences between patients infected by HIV, and is the first study of this kind in the field of infectious disease.

Results point to two gene variants related to the immune system. More precisely, these variations are in a genetic region responsible for the determination of immune response capacity against a number of infectious diseases, including AIDS.