PHILADELPHIA — Young adults who smoked water pipes in hookah bars had elevated levels of nicotine, cotinine, tobacco-related cancer-causing agents, and volatile organic compounds (VOC) in their urine, and this may increase their risk for cancer and other chronic diseases, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Massachusetts General Hospital (MGH) investigators have developed a transgenic mouse that synthesizes both the omega-3 and omega-6 essential fatty acids within its tissues on a diet of carbohydrates or saturated fats. Called "essential" because they are necessary to maintain important bodily functions, omega fatty acids cannot naturally be synthesized by mammals and therefore must be acquired by diet. Significant evidence suggest that the ratio of dietary omega-6 to omega-3 has important implications for human health, further increasing interest in the development of foods rich in omega-3s, which are found in certain species of fish as well as some nuts and green vegetables.

To quote the American cartoonist Gary Larson: all things play a role in nature, even the lowly worm—but perhaps never in such a visually stunning way as that presented in two papers published today in the open access journals GigaScience and PLOS ONE. The work and data presented here provide the first-ever comparative study of earthworm morphology and anatomy using a 3D non-invasive imaging technique called micro-computed tomography (or microCT), which digitizes worm structures. This opens the possibility of scanning millions of specimens from museum collections, including extinct species, all of which is important given that the earthworm is both a benefit and a bane to ecosystems.

Organisms inherit their mitochondria – the cell’s “power plants” – from their mothers, but what happens to all the father’s mitochondria?

Why and how are paternal mitochondria prevented from getting passed on to their offspring after fertilization? Just the randomness of evolution or is there a reason the phenomenon has been conserved?

"Subatomic particles act in quantum ways—they have a wave-like nature—and so can atoms, and so can whole molecules since they're collections of atoms," Schwab says. "So the question then is: Can you make bigger and bigger objects behave in these weird wave-like ways? Why not? Right now we're just trying to figure out where the boundary of quantum physics is," says Keith Schwab, Professor of Applied Physics at Caltech. 

And that means finding a way to make measurements that go beyond the limits of quantum physics.

Researchers have shown for the first time in an animal that is more closely related to humans that it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal's own skin cells. The study in monkeys reported in the Cell Press journal Cell Reports on May 15th also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.