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Who Else Is Annoyed At Having To Slow Down For Inactive Road Construction Sites?

We've all been driving and come upon signs warning us that construction is happening and we have...

Phase-Change Materials Set New Speed Limit For Silicon

As has been predicted for some time, there is a physics train wreck coming at the semiconductor...

Researchers Discover How Circular RNA Is Created

Circular RNA were discovered a few years ago, but their role in our bodies is poorly understood...

Double Mastectomy: 'Angelina Effect' Has Been Long-lasting

Referrals for genetic testing more than doubled across the UK after actress Angelina Jolie announced...

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The off-label use of a drug given with RU-486 to terminate a pregnancy may be responsible for a handful of rare, fatal infections seen in women taking the drugs since 2000, a study by University of Michigan scientists suggests. Preliminary U-M studies indicate that oral use of RU-486's companion drug misoprostol is safe, but vaginal use may undermine body's immune responses

The drug misoprostol is FDA-approved to be taken by mouth along with RU-486 to end a pregnancy. But many women have received the drug vaginally as part of the two-drug combination, a method of delivery not evaluated by the FDA.

In animal and cell culture studies, the U-M researchers found that misoprostol, when given directly in the reproductive tract, suppresses key immune responses and can allow a normally non-threatening bacterium, Clostridium sordellii, to gain the upper hand and cause deadly infection. When absorbed through the stomach, however, the drug did not compromise immune defenses or cause illness.

Since the Women's Health Initiative study found that long-term therapy with estrogen or estrogen plus progestin may increase the risk of heart attack and stroke, many women have found it difficult to decide whether to take hormone therapy at menopause.

Subsequently, several researchers have speculated that the timing of estrogen treatment may be important for estrogen's effects.

A group of authors therefore designed an animal study to determine if estrogen would be beneficial for females who are going through menopause (perimenopausal) but not for women who are postmenopausal for many years. Since it is not possible to measure "risk" in animal studies, the authors measured severity of stroke injury.

Bioengineers at the University of California, Berkeley in a new study published in Nature say they have identified two key regulatory pathways that control how well adult stem cells repair and replace damaged tissue. They then tweaked how those stem cells reacted to those biochemical signals to revive the ability of muscle tissue in old mice to repair itself nearly as well as the muscle in the mice's much younger counterparts.

Because the findings relate to adult stem cells that reside in existing tissue, this approach to rejuvenating degenerating muscle eliminates the ethical and medical complications associated with transplanting tissues grown from embryonic stem cells.

The researchers focused on the interplay of two competing molecular pathways that control the stem cells, which sit next to the mature, differentiated cells that make up our working body parts. When the mature cells are damaged or wear out, the stem cells are called into action to begin the process of rebuilding.


Whether your summer vacation plans involve staying close to home or crossing the globe, you'll want to put as much thought into protecting your health while traveling as you do choosing your destination. A new report, Healthy Travel: A 10-Minute Consult from Harvard Medical School, includes this list of important health-related items to take along:

Lockheed Martin's Aegis Ballistic Missile Defense (BMD) Weapon System successfully detected, tracked and intercepted a short- range unitary ballistic missile target in the terminal phase of its trajectory during a test at the Pacific Missile Range off the coast of Hawaii.

In the test mission, the SPY-1B radar on the Aegis BMD cruiser USS Lake Erie (CG 70) detected and tracked the ballistic missile target, and computed a targeting solution to guide two SM-2 Block IV missiles to a successful endo-atmospheric (within the atmosphere) intercept. Once the SM-2s were launched from the ship’s Lockheed Martin-developed MK-41 Vertical Launching System (VLS), Aegis guided the missiles through the terminal phase of the intercept. The SM-2 Block IV missiles were recently modified to perform the terminal phase endo-atmospheric intercept of a ballistic missile.


If you are curious about Earth's periodic mass extinction events such as the sudden demise of the dinosaurs 65 million years ago, you might consider crashing asteroids and sky-darkening super volcanoes as culprits.

But a new study suggests that it is the ocean, and in particular the epic ebbs and flows of sea level and sediment over the course of geologic time, that is the primary cause of the world's periodic mass extinctions during the past 500 million years.[1]

"The expansions and contractions of those environments have pretty profound effects on life on Earth," says Shanan Peters, a University of Wisconsin-Madison assistant professor of geology and geophysics and the author of the new Nature report.