Many neuronal disorders, including epilepsy, schizophrenia and lissencephaly – a form of mental retardation -, result from abnormal migration of nerve cells during the development of the brain. Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy, have now discovered that a protein that helps organising the cells’ skeleton is crucial for preventing such defects.

The voltage sensor of voltage-gated ion channels is a conserved protein domain that senses millivolt changes in transmembrane potential, to regulate ion permeation through the channel. A recently discovered protein, Ci-VSP, has a voltage sensor that is coupled not to an ion channel but to a phosphatidylinositide phosphosphatase, the activity of which depends on membrane potential.

In a new paper published in The Journal of Physiology, Murata and Okamura, from the Okazaki Institute for Integrative Bioscience, examine a voltage-sensitive phosphatase that converts an electrical to a chemical signal; they directly demonstrate that the enzyme activity of Ci-VSP changes in a voltage-dependent manner through the operation of the voltage sensor.

The brand-new Large Binocular Telescope (LBT) in Arizona has a gotten off to an astronomical start, helping an international team of astronomers learn that a recently discovered tiny companion galaxy to our Milky Way, named the Hercules Dwarf Galaxy, has truly exceptional properties: unlike the round tiny dwarf galaxies found so far, this neighbor 430,000 light years away is shaped more like a cigar.

The stars in many large galaxies are arranged in a disk-like configuration, like our Milky Way, but among the millions of well-studied tiny dwarf galaxies none has ever been observed to have a cigar-like shape before now.

An explanation for the galaxy's unusual shape is that it is being disrupted by the gravitational forces of the Milky Way.

Cholesterol level testing at about 15 months of age could prevent heart disease later in life, say doctors in a study published by British Medical Journal today.

Their rationale? Hereditary high cholesterol, known as familial hypercholesterolaemia, affects about two in every 1000 people and causes very high levels of low density lipoprotein (LDL) or ‘bad cholesterol’ in the blood. It carries a high risk of death from coronary heart disease.

Treatment to lower cholesterol reduces the risk substantially, but is it worth the expense to test all children for something that will impact .2% of the population?

The area covered by sea ice in the Arctic has shrunk to its lowest level this week since satellite measurements began nearly 30 years ago, opening up the Northwest Passage – a long-sought short cut between Europe and Asia that has been historically impassable.

In the mosaic image above, created from nearly 200 images acquired in early September 2007 by the Advanced Synthetic Aperture Radar (ASAR) instrument aboard ESA’s Envisat satellite, the dark gray colour represents the ice-free areas while green represents areas with sea ice.

Leif Toudal Pedersen from the Danish National Space Centre said: "We have seen the ice-covered area drop to just around 3 million sq km which is about 1 million sq km less than the previous minima of 2005 and 2006.

The international car industry is currently presenting many environmentally friendly models at the IAA, the biggest car exhibition in the world. Can the idea sell in the home of Aston-Martin and Jaguar?

Estimates say 64% of British drivers could use hybrids and 21% are thinking hybrid for their next new car. They would even be willing to pay $1900 more than for a conventional car, according to market research institute Maritz Research.

"There is huge enthusiasm for hybrids amongst British consumers," explains Christian Vorwerck, director of marketing at Maritz Research. "The potential for the car industry is massive."