Researchers at Medical University of Vienna say it is possible for a blood test to detect depression.
Mental illness in the blood? They say, in principle, depression can be diagnosed. Serotonin transporter (SERT) is a protein in the cell membrane that facilitates the transport of the neurotransmitter serotonin (the "happiness hormone") into the cell. In the brain, serotonin transporter regulates neural depression networks. Depressive conditions can frequently be caused by a lack of serotonin.
As a result, the serotonin transporter is also the point of action for the major antidepressant drugs. But the serotonin transporter also occurs in large quantities in numerous other organs such as the intestines or blood. Recent studies have shown that the serotonin transporter in the blood works in exactly the same way as in the brain. In the blood, it ensures that blood platelets maintain the appropriate concentration of serotonin in the blood plasma.
Credit: Medical University of Vienna
Medical University of Vienna
say functional magnetic resonance imaging of the brain and pharmacological investigations demonstrate that there is a close relationship between the speed of the serotonin uptake in blood platelets and the function of a depression network in the brain.
This network is termed the “default mode network” because it is primarily active at rest and processes content with strong self-reference. Findings from recent years have also demonstrated that it is actively suppressed during complex thought processes, which is essential for adequate levels of concentration. Interestingly, patients with depression find it difficult to suppress this network during thought processes, leading to negative thoughts and ruminations as well as poor concentration.
Some caution is warranted. fMRI studies have shown very little scientifically that has held up and linking serotonin in blood to psychology using them is going to take a lot of convincing.
“This is the first study that has been able to predict the activity of a major depression network in the brain using a blood test. While blood tests for mental illnesses have until recently been regarded as impossible, this study clearly shows that a blood test is possible in principle for diagnosing depression and could become reality in the not too distant future," says study leader Lukas Pezawas from the Department of Biological Psychiatry at the University Department of Psychiatry and Psychotherapy within the MedUni Vienna.
Scharinger C, Rabl U, Kasess CH, Meyer BM, Hofmaier T, Diers K, Bartova L, Pail G, Huf W, Uzelac Z, Hartinger B, Kalcher K, Perkmann T, Haslacher H, Meyer-Lindenberg A, Kasper S, Freissmuth M, Windischberger C, Willeit M, Lanzenberger R, Esterbauer H, Brocke B, Moser E, Sitte HH, Pezawas L. (2014) Platelet serotonin transporter function predicts default-mode network activity. PLoS One 9: e92543
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Family Holiday Survival: 12 Ways To Deal With That Climate Change Denier
- A Vegetarian Carnivorous Plant...Wait, What?
- Falsifiability And The Integrity Of Physics
- Wave-Particle Duality And Quantum Uncertainty - Two Sides Of The Same Mystery?
- Guest Post: Ben Allanach, On Open Access
- Dr. Ozvorkian And The Amoebas
- How Does Prostate Cancer Happen?
- "As a layman, I have some faith in Einstien. The reasons are because the well established experimental..."
- "When I run into the religious Climate Change believers I just start showing them one of the dozens..."
- "In the real world we don't know enough to accurately predict the effects of anything on anything..."
- "As one who has more than dabbled in the area of Quantum Gravity for years I agree with this.  ..."
- "Explain to me how attacking Mehmet Oz over and over again makes people safe? He isn't killing..."
- iPads and other Light-emitting e-readers detrimentally shift circadian clock
- Cope with climate change by shape-shifting
- Clarithromycin-statin mix can cause drug interactions and hospitalization
- E-books before bedtime can adversely impact sleep
- Disabled, ethnic men more likely to do 'women's work' - paper