Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA.
Investigating all transcripts produced in a yeast cell, researchers in the groups of Lars Steinmetz at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and Wolfgang Huber at the European Bioinformatics Institute (EMBL-EBI) in Hinxton, UK found that most regions of the yeast genome produce several transcripts starting at the same promoter. These transcripts are interleaved and overlapping on the DNA. In contrast to what was previously thought, the vast majority of promoters seem to initiate transcription in both directions.
Their study in Nature says it redefines the concept of promoters (the start sites of transcription) contradicting the established notion that they support transcription in one direction only. The results are also representative of transcription in humans, they write.
So is transcription about to get Pluto'ed? Let's not rewrite the textbooks just yet.
Not all of the produced transcripts are stable, many are degraded rapidly making it difficult to observe what they do.
While some of the RNA molecules might be 'transcriptional noise' without function, other transcripts control the expression of genes and production of proteins. The act of transcription itself is also likely to play an important role in regulation of gene expression. Transcribing one stretch of DNA might either help or in other cases interfere with the transcription of a gene close by. Moreover, transcripts without a current purpose can serve as 'raw material for evolution' and acquire new functions over time.
The results shed light on the complex organization of the yeast genome and the insights gained extend to transcription in humans. A better understanding of transcription mechanisms could find application in new technologies to tune gene regulation in the future.
Article: Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Münster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W.&Steinmetz, L.M. Bidirectional promoters generate pervasive transcription in yeast, Nature, 25 January 2009
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Case For Moon: Gateway To Open Ended Human Exploration, With Planetary Protection Central - On The SpaceShow
- B0 Meson Lifetime Difference Measured By ATLAS
- The Real Cost Of Milk
- Can't Resist Temptation? That May Not Be A Bad Thing
- Italian Food Scientists Are Tired Of Phony Cheese
- Sweet Irony: The Environmental Impacts Of GMO Sugar Science Denial
- After Losing In Government, Environmental Groups Embrace The Free Market
- "Homeopathy is based on the ‘like cures like’ principle: if a substance causes a set of symptoms..."
- "scuentific ?????????..."
- "Irrefutable evidence? This is not in agreement with the falsability criteria. Is dogmatism...."
- "Ernst has shown many times, through reviews of studies that homeopathy does not work. 2002 Review..."
- "And pseudoskeptik said Homoeopathy end of debate... ..."
- Genes that increase children's risk of blood infection identified
- Mimicking deep sleep brain activity improves memory
- Making or breaking habits: The endocannabinoids can do it
- Malnutrition results from more than just inadequate diet
- TSRI scientists discover mechanism that turns mutant cells into aggressive cancers