The question of whether insulin-producing cells of the pancreas can regenerate is key to our understanding of diabetes, and to the further development of regenerative therapies against the disease. Dr Rosenberg from the McGill University Health Centre (MUHC) and McGill University together with Dr Bernard Massie from the Centre hospitalier de l'Université de Montréal (CHUM) have just concluded that they can. The results of their study have been published in the July issue of the journal Laboratory Investigation.
The researchers have shown in vitro that insulin-producing β-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This process is known as "dedifferentiation" and highlights the plasticity of this cell type. This same result has also been validated for the three additional types of cells that – along with β-cells – make up the islets of Langerhans. Together, these islet cells produce insulin and other hormones in the pancreas.
"The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," Dr. Rosenberg said.
"At this stage, we can't confirm whether the cells' ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes," he continued. The cell's in-vitro plasticity opens up totally new avenues of investigation into the underlying causes of diabetes, and will validate the development of innovative treatments.
This study is the latest step in an extensive regenerative therapies research program based on a peptide called Islet Neogenesis Associated Protein, or INGAP. Dr. Rosenberg and his colleagues have demonstrated INGAP's potential to induce new islet formation in the pancreas. Clinical trials with INGAP have already demonstrated that it is possible to regrow new functional insulin-producing cells in diabetic patients.
"We know that the peptide works, but we are still lacking certain theoretical bases to explain its mechanism," said Dr. Rosenberg. "This finding will allow us to move ahead on firmer ground."
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- 3X Saturated Fat In The Diet Doesn't Increase It In Blood
- Eosinophilic Esophagitis: Genetic Clues Of Severe Food Allergy
- Still No Contact with NASA's Sun-watching Probe
- Interstellar Is A Dangerous Fantasy Of US Colonialism
- Extraordinary Claims: Review My Paper For $10
- Want A Man To Help? High Heels Work
- "As an earlier cigarette smoker and now e-cig smoker, I can confirm they don't help you quit. As..."
- "Reality? What is reality if you use irrational arguments to justify man's cruelty toward..."
- "Always loved the Heels that showed of the instep (arches) ..."
- "By the way, I am a fan of your blog. It's one of the few places I can follow physics without getting..."
- "Hello Anon,you're entirely right, it's arbitrary and it does not provide protection against cases..."
- Gene in kidney may play role in high blood pressure
- Panel-based genetic diagnostic testing for inherited eye disease proves highly accurate
- Research finds tooth enamel fast-track in humans
- Good news for cocaine users: Caffeine counters cocaine's effects on women's estrus cycles
- Clipping proteins that package genes may limit abnormal cell growth in tumors