The question of whether insulin-producing cells of the pancreas can regenerate is key to our understanding of diabetes, and to the further development of regenerative therapies against the disease. Dr Rosenberg from the McGill University Health Centre (MUHC) and McGill University together with Dr Bernard Massie from the Centre hospitalier de l'Université de Montréal (CHUM) have just concluded that they can. The results of their study have been published in the July issue of the journal Laboratory Investigation.
The researchers have shown in vitro that insulin-producing β-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This process is known as "dedifferentiation" and highlights the plasticity of this cell type. This same result has also been validated for the three additional types of cells that – along with β-cells – make up the islets of Langerhans. Together, these islet cells produce insulin and other hormones in the pancreas.
"The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," Dr. Rosenberg said.
"At this stage, we can't confirm whether the cells' ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes," he continued. The cell's in-vitro plasticity opens up totally new avenues of investigation into the underlying causes of diabetes, and will validate the development of innovative treatments.
This study is the latest step in an extensive regenerative therapies research program based on a peptide called Islet Neogenesis Associated Protein, or INGAP. Dr. Rosenberg and his colleagues have demonstrated INGAP's potential to induce new islet formation in the pancreas. Clinical trials with INGAP have already demonstrated that it is possible to regrow new functional insulin-producing cells in diabetic patients.
"We know that the peptide works, but we are still lacking certain theoretical bases to explain its mechanism," said Dr. Rosenberg. "This finding will allow us to move ahead on firmer ground."
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Pseudoscience Creeping Into Your Conference? A Case In GMOs And Glyphosate
- My Thoughts On The LIGO-VIRGO Result
- Beyond Diamonds And Gems: The World's Rarest Minerals
- Henri Poincaré Predicted The Existence Of Gravitational Waves As Early As June 5, 1905
- Gravitational Waves? Watch the LIGO press conference at 10:30 Eastern.
- The 10 catastrophic mistakes virtual reality firms are making
- When Machines Can Do Any Job, What Will Humans Do?
- "That reminds me of the chemiosmotic war that followed Peter Mitchell's publication of his theory..."
- "The American Physical Society (APS) has allowed physics crackpots to attend conferences for years..."
- "A further comment on the meaning of Poincaré's prediction about gravitational waves : the classical..."
- "Dear Tomasso I have a simple question: What is the probability of a chirped wave train of 20ms..."
- "Ciao Giulio - I work on the LIGO and Virgo instruments, I can try to explain. The arms in LIGO..."
- Beard Microbiology: Grubby Hipsters May Be On To Something
- Water Tops the List of Health Concerns for Competitive Eaters
- Natural Flavors Are More Radioactive Than Artificial Ones.
- Bariatric Surgery Beneficial Even for Older People
- Opiates No Better at Easing Knee Osteoarthritis Pain
- BRCA Tests Increasing for Younger Breast Cancer Patients
- Dark matter scientists on brink of discovering elusive particles
- Science responds to globalized disease threat to farms and food systems
- Americans' support for science remains strong
- Loss of sleep during adolescence may be a diabetes danger
- Study of cognitive development in deaf children revisits longstanding debate