The human body is home to a diverse range of microorganisms, estimated to outnumber human cells in a healthy adult by ten fold. The importance of characterizing human microbiota for understanding health and disease is highlighted by the recent launch of the Human Microbiome Project by the National Institutes of Health. This report describes the investigation of healthy human skin for microbiota diversity and establishes the basis for determining a core microbiome.
The Human Microbiome Project aims to characterize the microbial communities of several regions of the body, including skin, where determining the core microbiome is essential to understanding and developing new treatments for skin conditions and diseases such as acne and atopic dermatitis (eczema).
In this study, researchers led by Dr. Julie Segre of the National Human Genome Research Institute have generated a diversity profile of human skin microbiota by sequencing 16S rRNA, a component of the prokaryotic ribosome, isolated from a specific region of skin. “We focused this study on the inner elbow to inform future clinical studies of the extremely common inflammatory skin disorder atopic dermatitis, which affects this area of the skin and is associated with Staphylococcus infections,” explains Segre.
The researchers find that in the healthy subjects tested, Proteobacteria (predominantly Pseudomonas and Janthinobacterium) constituted the majority of inner elbow microbiota. Furthermore, this survey indicated that a common core skin microbiome exists between these individuals. Segre adds that this finding is critical for studying disease. “Our long-term goal is to clarify the microbial contribution to a myriad of skin disorders both with known and suspected bacterial infections.“ Segre’s group also found that the microbiota of mouse skin is comparable to that of the human inner elbow, suggesting a potential model for human skin disorders related to microbiota.
Segre explains that this work has established a foundation for answering questions about microbiota and skin disease, with the potential for novel drugs and treatments. “It's not surprising that microbes play a vital role in human health and disease,” says Segre. “Unfortunately the public is conditioned to view microbes antagonistically, when in fact they may hold the key to a whole new array of therapeutic options.”
Scientists from the National Human Genome Research Institute (Bethesda, MD) and the National Cancer Institute (Bethesda, MD) contributed to this study.
This work was supported by the National Institute of General Medical Sciences, the National Human Genome Research Institute, and the National Cancer Institute.
Citation: Grice, E.A., Kong, H.H., Renaud, G., Young, A.C., NISC Comparative Sequencing Program, Bouffard, G.G., Blakesley, R.W., Wolfsberg, T.G., Turner, M.L., and Segre, J.A. A diversity profile of the human skin microbiota. Genome Res. doi:10.1101/gr.075549.107.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Microwave Electron Guns: A Field-Emission Plug-And-Play Solution
- Interstellar Is A Dangerous Fantasy Of US Colonialism
- Extraordinary Claims: Review My Paper For $10
- The BPA Paradox – Too Many Studies?
- In A Snowstorm, Do You Want Salt Or Vegetable Juice On Your Road?
- Why We Can't "Backup Earth" On Mars, The Moon, Or Anywhere Else In Our Solar System
- "Just to say - you don't need to colonize space to have the capability to go into space. And - arguably..."
- "I disagree completely! We should colonize space because we can. Whenever else would we do it? We..."
- "The worst possible reason to do something is just because we can.It is respectable, even admirable..."
- "There's only so much American continent, but there's plenty of outer space for everyone.(Actually..."
- "You might find this paper quite useful? The shift toward numerical naturalness was an important..."