NAPA, California, November 14 /PRNewswire/ --

- Senetek is Debt-Free with Cash on Hand of US$16.7 million at September 30

- Annual General Meeting and Concurrent Broadcast Scheduled for December 16

Senetek PLC (OTC Bulletin Board: SNKTY), a Life Sciences company engaged in the development of technologies that target the science of healthy aging, today announced financial results for the quarter ended September 30, 2008.

Revenue for the quarter ended September 30, 2008 was US$483,000, compared with US$469,000 reported in the third quarter of 2007.

Net loss for the quarter ended September 30, 2008 totaled US$1,050,000, or US$0.14 per share compared to a net loss of US$998,000 or US$0.13 per share in the third quarter of 2007.

Cash and cash equivalents totaling US$16,687,000, or US$2.18 per share at September 30, 2008 represents the resources necessary to meet operating requirements for the foreseeable future.

Senetek's Annual General Meeting will be held at the Meritage Hotel, 875 Bordeaux Way, Napa, California, 94558, on Tuesday, December 16, 2008 at 10:00 a.m. Pacific Standard Time. The Meeting Notice, Proxy Statement and Voting Cards have been mailed to all shareholders.

Senetek's Annual General Meeting will be broadcast live to non-attending shareholders via Webex at http://senetek.webex.com and will be available for replay at the same location through December 23, 2008.

About Senetek PLC

Senetek PLC (OTCBB: SNKTY) is a Life Sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The Company's extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of the best-selling anti-aging product sold in the North American physician market. For more information, visit the company's website at http://www.senetekplc.com.

This news release contains statements that may be considered 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act. Forward-looking statements by their nature involve substantial uncertainty, and actual results may differ materially from those that might be suggested by such statements. Important factors identified by the Company that it believes could result in such material differences are described in the Company's Annual Report on Form 10-K for the year 2007. However, the Company necessarily can give no assurance that it has identified or will identify all of the factors that may result in any particular forward-looking statement materially differing from actual results, and the Company assumes no obligation to correct or update any forward-looking statements which may prove to be inaccurate, whether as a result of new information, future events or otherwise.

Michael Rogers, +1-212-255-7210, michael@michaelrogerspr.com, for Senetek PLC