The discovery was the result of studies performed in two groups of mice. The first group of mice was normal, but the second was missing a gene from the peritubular myoid cells in the testis. This missing gene codes for the androgen hormone receptor, and when missing, sperm production was significantly decreased when compared to the normal group. The result was infertility.
The research could open a promising avenue for the development of "the pill" for men. The discovery also offers hope to those who cannot have children because of low sperm counts. Although the research was conducted in mice, a similar effect is likely to be obtain in other mammals, such as humans.
"This study provides a new opportunity to identify how androgens control sperm production, which could provide new insight for the development of new treatments for male infertility and perhaps new male contraceptives," said Michelle Welsh, Ph.D., co-author of the study, from the Centre for Reproductive Biology at The Queen's Medical Research Institute in Edinburgh, UK.
"Although 'the pill' arguably has been liberating for women since its development in the 1960s, a similar birth control drug for men has been elusive," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Not only does this research pinpoint androgenic hormones and their cellular receptors as prime targets for the development of new birth control drugs, but it promises to speed the development of new agents to boost sperm production."
Citation: Michelle Welsh, Philippa T. K. Saunders, Nina Atanassova, Richard M. Sharpe, Lee B. Smith, 'Androgen action via testicular peritubular myoid cells is essential for male fertility', The FASEB Journal, 2009, doi: 10.1096/fj.09-138347