Genetics & Molecular Biology

In 2013, stem cell therapy is touted as the future of medicine by proponents in Europe and Asia while scientists in America urge caution. Contrast that to a decade ago, when the concern was that American President George W. Bush was holding back progress because he limited federal funding for one form of stem cell research. In 2012, Governor Rick Perry of Texas not only believed in stem cell research, he declared that he wanted to make his state the home of American stem cell science.

Scientists in the UK, Portugal and Germany solved the structure of kynurenine 3-monooxygenase (KMO), a protein implicated in the neurodegeneration (destruction of nerve cells) seen in diseases associated with old age, such as Alzheimer’s, Parkinson’s and Huntington’s.

 It also reveals how to block KMO in a major first step to develop a promising new therapeutic approach for a group of diseases that, despite affecting millions worldwide, remain without cure or treatment. 

Men with Lynch syndrome, an inherited genetic condition linked to a higher risk of several types of cancer, face a higher lifetime risk of developing prostate cancer and appear to develop the disease at an earlier age, according to a new study.

People with Lynch syndrome have up to 80 percent lifetime risk of colorectal cancer and are also more likely to develop endometrial, gastric, ovarian, urinary tract, pancreatic and brain tumors. Overall, about 1 in 440 people are carriers for the genetic mutation, making it one of the most common inherited cancer conditions.


Two manuscripts related to the ancestral wheat genomes of Triticum urartu and Aegilops tauschii  provide an unprecedented glimpse into the adaptation and domestication of wheat throughout the ages and shedding light on the biology of the world's primary staple crop. 


In the early 1950's, a 66-year-old woman with colon cancer received a blood transfusion - but she suffered a severe rejection of the transfused blood. When writing the case study, the medical journal Revue D'Hématologie identified her only as "Patient Vel."

It was determined that Mrs. Vel had developed a potent antibody against some unknown molecule found on the red blood cells of most people in the world—but not found on her own red blood cells. But the molecule was unknown, nobody could find it. A blood mystery began, and, from her case, a new blood type, "Vel-negative," was described in 1952.


The Lazarus Project team says they have been able to recover cell nuclei of the extinct gastric-brooding frog, Rheobatrachus silus,
from tissues collected in the 1970s and kept for 40 years in a conventional deep freezer. 

The genome of
Rheobatrachus silus, extinct since 1983, has been revived and reactivated by a team of scientists using
somatic cell nuclear transfer
to implant a "dead" cell nucleus into a fresh egg from another frog species.
 

Rheobatrachus silus is famous for swallowing its eggs, brooded its young in its stomach and giving birth through its mouth. The "de-extinction" project aims to bring the frog back to life.
 


When Whole Foods announced it will require all of the products on its shelves to have their GMO contents labeled by 2018, the company framed it as an issue of transparency.  ”People have the right to know what is in their food,” said Whole Foods co-CEO John Mackey, quoting the favorite catchphrase of GMO labeling activists. Unfortunately, GMO labeling is likely to achieve exactly the opposite of transparency.

Beating heart cells (cardiomyocytes) are often used as an empowering imagery to depict important scientific advances in stem cell technology; advances that enable scientists to harness human embryonic stem cells to regenerate tissues that cannot easily be replaced, including heart tissue. From the use of controversial human embryonic stem cells, to Yamanaka's discovery of an engineering technology to reprogram human skin cells into cells that are akin to embryonic stem cells (dubbed induced pluripotent stem cells); the beating cardiomyocytes remain a media cliché representing our society's advances in stem cell technology and regenerative medicine.

HeLa cells, named after Henrietta Lacks, whose cells, which were cultured by George Otto Gey to create an immortal cell line for medical research, are the world's most commonly used human cell lines and have served as a standard for understanding many fundamental biological processes.

In a new study published today, scientists announce they have successfully sequenced the genome of a HeLa cell line and their high-resolution genomic reference reveals the striking differences between the HeLa genome and that of normal human cells. 

Is your body shape predetermined? Some role for heritage is obvious and there efforts to fix people into an epigenetic destiny as well but it may be that diet and exercise can only do so much. A new paper says body composition, including soft fat tissue and hard bone tissue, which can lead to excess fat or osteoporosis, is genetic.

Prof. Gregory Livshits and Dr. Michael Korostishevsky of Tel Aviv University's Department of Anatomy and Anthropology say they have uncovered a clear genetic link between fat and bone mass. These factors, which contribute to bone metabolism, also affect Body Mass Index (BMI), which often serves as an indicator of overall health.