Genetics & Molecular Biology

Bees play an invaluable role in maintaining biodiversity and in pollinating the crops that feed the world, so it is essential to improve our understanding of their biology and to investigate how they respond to environmental threats. Despite their often slow and apparently bumbling flights from flower to flower, bumblebees are anything but lazy. With over 250 bumblebee species globally, these important insects perform the laborious task of pollinating flowers in both wild and agricultural settings. A large number of fruits and vegetables would be missing from our plates had a bumblebee not done its job. 

Centrioles - barrel-shaped structures inside cells- are made up of multiple proteins and since mutations in the proteins that make them up can cause a broad range of diseases, including developmental abnormalities, respiratory conditions, male sterility and cancer, they are the focus of a great deal of research

There may be more a natural way to reduce the use of pesticides but still save plants from attack -  by recreating a natural insect repellent based on smell.

Scientists from Cardiff University and Rothamsted Research have created tiny molecules which mirror a natural occurring smell known to repel insects by providing the enzyme ((S)-germacrene D synthase), which creates the smell, with alternative substrate molecules. 

The effectiveness of the smell or perfume to function as an insect repellent was tested and the team found that the smells repelled insects but in one case a reversal of behavior - an attractant - was observed which raises the prospect of being able to develop a trap-and-kill device. 

Stem cells cling to feeder cells as they grow in petri dishes and it has been thought that this attachment occurs because feeder cells serve as a support system, providing stems cells with essential nutrients.

A proof-of-concept study in mice showed it is possible to prevent transmission of mitochondrial disease to children without resorting to controversial cytoplasmic transfer - "three-parent" IVF.

Mitochondria are known as the powerhouse of the cell because they generate most of the cell's supply of energy. Each cell in the body contains anywhere from 1,000 to 100,000 copies of mitochondrial DNA, which is exclusively transmitted through maternal inheritance. In most patients with mitochondrial disease, mutated and normal mitochondrial DNA molecules are mixed together in cells.

Tumor necrosis factor (TNF), an immune system regulatory protein that promotes inflammation, also helps regulate sensitivity to bitter taste, a finding which may provide a mechanism to explain the taste system abnormalities and decreased food intake that can be associated with infections, autoimmune disorders, and chronic inflammatory diseases. 

Because TNF is known to suppress food intake, the current study asked whether TNF affects food intake via the taste system. The findings are published online ahead of print in the journal Brain, Behavior, and Immunity.

Sweet potatoes, one of the most important food crops for human consumption, contain genes from the bacterium Agrobacterium but that was not done by scientists. The foreign DNA that turned sweet potatoes into a GMO was put there by nature.

The researchers discovered the foreign DNA sequences of Agrobacterium while searching the genome - this is the entire DNA-code - of sweet potato for viral diseases. Instead of contributing this peculiar finding to bacterial contamination of the plant samples, the researchers decided to study these sequences in more detail.

Female liver cells, and in particular those in post-menopausal women, are more susceptible to adverse effects of drugs than their male counterparts, according to new research carried out by the European Commission, Joint Research Centre (JRC).

It is established that women are more vulnerable than men when it comes to drug-induced liver effects, but this is the first time it has been shown that there are differences at cellular level. The findings are clinically relevant, and emphasize the importance of considering sex-based differences in human health risk assessment.

Researchers have identified an important cause of why secondary corneal transplants are rejected at triple the rate of first-time corneal transplants.

The cornea - the most frequently transplanted solid tissue - has a first-time transplantation success rate of about 90 percent. But second corneal transplants undergo a rejection rate three times that of first transplants.

More than 40,000 transplants are performed annually to replace the cornea, the clear outer lens at the front of the eye, with tissue from a donor. Most corneal transplants are done to correct severe visual impairments caused by keratoconus, a condition in which the normally dome-shaped cornea progressively thins and becomes cone-shaped, according to the American Academy of Ophthalmology.

Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery unveils a whole new set of potential targets: the RNA intermediaries between DNA and proteins.

This RNA, called messenger RNA, is a blueprint for making proteins. Messenger RNA is created in the nucleus and shuttled out into the cell cytoplasm to hook up with protein-making machinery, the ribosome. Most scientists have assumed that these mRNA molecules are, aside from their unique sequences, generic, with few distinguishing characteristics that could serve as an Achilles heel for targeted drugs.