Genetics & Molecular Biology
Scientists at the universities in Tübingen and Mainz say they have developed a blood test that can provide conclusive proof of gene doping - even after 56 days.
To date, it has been impossible to prove that an athlete had undergone gene doping but they say the new test provides a clear answer based on whether or not transgenic DNA is present in blood samples. Transgenic DNA (tDNA) does not stem from the person being tested but has been transferred into their body, often via viruses, in order to create performance-enhancing substances such as erythropoetin (EPO) for forming red blood cells.
The human genome is the home of over 3 billion nucleotide base pairs packaged into 23 chromosome pairs. But despite the tremendous size of the human genome, only 1-2% of genome actually encodes for proteins.
Researchers at the Buck Institute for Age Research writing in the journal Stem Cells say they have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson's Disease (PD).
They say the research validates a scalable protocol that the same group had previously developed and can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC's in various biomedical applications.
iPSC research has come strongly into play during the last few years because of limitations on human embryonic stem cell research in the Bush and Obama administrations and are a hot topic among scientists focused on regenerative medicine.
Researchers at the RIKEN Center for Developmental Biology say they have unraveled the mystery of why human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells undergo apoptosis (programmed cell death) when cultured in isolation, a discovery that promises new hope to sufferers of debilitating degenerative diseases.
Thimios Mitsiadis, Professor for Oral Biology at the University of Zurich, says he has shown that during tooth formation (odontogenesis) if the Jagged2 gene is inactivated, and thus the Notch signaling pathway is interrupted, tooth crowns will be malformed and enamel will be lacking.
Signaling pathways cells react to signals from their environment and one of the most important signaling pathways is the Notch signaling pathway. It is evolutionary conserved to a very high degree and it is involved in the development of all organs and tissues in animal and human embryos.
In a new Cell study, researchers say they have uncovered a new role for an essential cell protein polynucleotide phosphorylase (PNPASE) in shuttling RNA into the mitochondria, the energy-producing 'power plant' of the cell.
The import of nucleus-encoded small RNAs into mitochondria is essential for the replication, transcription and translation of the mitochondrial genome, but the mechanisms that deliver RNA into mitochondria remain poorly understood.
John Mattick, University of Queensland, is one of the leading proponents of the idea that much -- perhaps most
-- of the human genome is functional. He has been making claims along these lines for at least 15 years
, but seems to always present it as a new idea. Readers of this blog may also remember the Dog's Ass Plot
included in one of his publications.
Genes specific to sex change rapidly but there is one sex-specific gene so vital its function has remained unaltered throughout evolution and is found in almost all animals, according to new research from Northwestern University Feinberg School of Medicine.
The gene, called Boule, is responsible for sperm production and they say that Boule appears to be the only gene known to be exclusively required for sperm production from an insect to a mammal.
Can somatic cells be reprogrammed to become pluripotent stem cells? Well, the answer is yes or no, depending on your perspective, and perhaps your definition of what pluripotent stem cells should be.
The cell membrane at first may seem a simple device, but it is in fact a very complex machine. The basic building block is the phospholipid, a set of molecules that have hydrophilic (water loving) heads on one side and a hydrophobic (water hating) tail on the other. Because of this relationship the water loving heads want to be near aqueous environments and the water hating tails like to be near other water hating tails, or fats. Since cells live in aqueous environments, and are filled with aqueous fluids the cell membrane forms two layers with the heads pointing out and the tails pointing towards each other.