Genetics & Molecular Biology

Does science really need to give Tiger Woods/Brett Favre an excuse?

"Sorry, sweetheart, I didn't mean to bang anything with a hole and a heart beat that came my way/text that chick pictures of my junk. But you have to forgive me because it's in my DNA. Oh look, it's tee time/game time again."
A new study was released today in JAMA which looked at, in part, mitochondrial DNA overreplication in a sample of ten autistic children between the ages of 2 and 5 and ten matched controls.  Giulivi et al. found that 5 of the 10 autistic children and 2 of the control children had mitchondrial DNA overreplication.

In the comments section of a previous post, the question was raised of how autism is diagnosed in the samples being studied. This new study allows an opportunity to look at how carefully the sample is selected and controls matched to the sample.
Researchers conducting genome-wide association studies say they have discovered 30 new genes determine the age of sexual maturation in women - and many of those genes also act on body weight regulation or biological pathways related to fat metabolism.

Menarche, the onset of first menstruation in girls, indicates the attainment of reproductive capacity and is a widely used marker of pubertal timing. Age of menarche varies widely and is highly dependent on nutritional status and early menarche is associated with many adverse health outcomes later in life, including breast cancer, endometrial cancer, obesity, type 2 diabetes and cardiovascular disease, as well as shorter adult stature.

Not having had any serious biological training I have to go to Wikipedia and Google to learn the basics. And I’m often surprised to find that concepts everyone uses don’t have good consensus amongst scientists. When reading the Wikipedia entry for “gene”, it occurs to me that if the concept didn’t predate the discovery of DNA, it would not exist.

At the very least, it would look much different than “a locatable region of genomic sequence, corresponding to a unit of inheritance” (call this the “standard definition”).

The ethical issues surrounding unchecked human embryonic stem cell research are not going away any time soon, regardless of which political party occupies Congress or the White House.   

Given that, researchers have devised various alternatives and now scientists at the Max Planck Institute for Molecular Genetics in Berlin have added one more.   They have managed to convert amniotic fluid cells into induced pluripotent stem cells (iPS cells). These amniotic fluid-derived iPS cells are hardly distinguishable from embryonic stem cells - however, they 'remember' where they came from.
Oxytocin, dubbed the "cuddle hormone" because of its importance in bonding ,  is best known for its role in childbirth and breastfeeding, and animal studies have shown that it may also be important in monogamous social relationships. Recently, economic research in humans implicated oxytocin in trust and empathy.

Additional animal research shows that oxytocin may relieve stress and anxiety in social settings and may be more rewarding than cocaine to new mothers.
Proteins are the indispensable catalytic workhorses, carrying out the processes essential to life in today's sophisticated organisms, but long ago ribonucleic acid (RNA) reigned supreme.

Researchers have produced an atomic picture that shows how two of these very old molecules interact with each other and it provides a rare glimpse into the transition from an ancient, RNA-based world to our present, protein-catalyst dominated world. 
'Agouti' is a family of genes previously identified in humans and the first two members are responsible for skin and hair color. Identified by Vanderbilt scientists, AgRP2 the newest member of the family, exclusively found in bony fishes and is claimed to be responsible for the ability of fish to rapidly change color!

AgRP2 in Zebrafish
Can there be a genetic difference between progressives and conservatives?   Certainly we have had the discussion many times about studies, both sociological and biological, seeking to make the case that politics might be nature as well as nurture.
The jokes write themselves, really:

"Ozzy Osbourne's Genome Reveals Some Neandertal Lineage"

The idea itself is fascinating, though, and I am interested to see what more they can mine from the PoD (Prince of Darkness, to the uninitiated). I nominate the full contingent of Mötley Crüe as the next genetic guinea pigs, testing for why people who should by all accounts be dead are still alive and shouting at the devil.