Scientists know that information travels between brain cells along hairlike extensions called axons. For the first time, researchers have found that axons don’t just transmit information – they can turn the signal up or down with the right stimulation.
This finding may help scientists develop treatments for psychiatric disorders such as depression and schizophrenia in which it is thought that different parts of the brain do not communicate correctly with each other.
“Until now, scientists have thought that in the brain’s cortex -- where most cognitive processes occur -- information was only processed in the cell body,” said Raju Metherate, author of the study, associate professor of neurobiology and behavior, and director of the Center for Hearing Research at UC Irvine. “The result of our study suggests that we must consider the axons as sites of information processing – and of potential problems when things go wrong.”
This study appears online Aug. 19 in Nature Neuroscience.
Increasingly, studies are beginning to show that complex information processing, and perhaps consciousness itself, may result from coordinated activity among many parts of the brain connected by bundles of long axons. Cognitive problems may occur when these areas don’t communicate properly with each other.
Cognitive function occurs when millions of brain cells communicate with each other at the same time. A brain cell has a network of branches called dendrites through which it receives and processes information from other cells. The body of the cell then relays the processed information along an axon to a terminal that links to another cell’s dendrites. At the terminal, chemicals called neurotransmitters are released, allowing the information to enter the receiving cell. Until now, scientists believed axons were just the wires between point A and point B.
“Axons, we thought, were like wires in a radio conveying signals, but we found that if you stimulate the axon, the signal can be altered, like turning the volume knob on the radio,” Metherate said.
Originally, Metherate and his colleagues had hoped to confirm the idea that the drug nicotine alters information that is processed in the cell body or terminal. Puzzled by several negative tests, they developed an experiment in which they could study the intervening axon.
In their experiment, they examined a section of mouse brain associated with hearing that contained a brain cell with an axon connecting to the cortex. Using nicotine, they stimulated the axon to determine how it would affect a signal the brain cell sent to the cortex. Without applying nicotine, about 35 percent of the messages sent by the brain cell reached the cortex. But when nicotine was applied to the axon, the success rate nearly doubled to about 70 percent.
“We looked for more conventional reasons why the response was enhanced, but the evidence just kept pointing to the axon. Nicotine activated the proteins that we think are on the axon,” Metherate said. “This is a completely new idea about how the brain works.”
UCI researchers Hideki Kawai and Ronit Lazar also worked on this study, which was funded by the National Institute on Drug Abuse and the National Institute on Deafness and Other Communication Disorders, both part of the National Institutes of Health.
Source: University of California - Irvine
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Robot Tongue Identifies The Correct Beer Every Time
- Mystery Of Morgellons - Disease Or Delusion - Scientific Hypothesis Of Connection With Lyme Disease
- Illegal Immigration To The U.S. Caused By Globalization?
- Brain-Computer Interface Makes Communication For Kids With Cerebral Palsy Easier
- Numenta And IBM To Build Biologically Inspired Intelligent Machines.
- Satellites Catch Birth Of Two Volcanic Islands In Yemen
- Editorial Independence Or Extortion? Frontiers Sacks 31 Editors
- "Is there any chance this would work on bedbugs? They may not normally carry lethal infections..."
- "This is supported by the following study, which itself begged the question of From whence came..."
- "Hi MB,Sorry but I can't help you - I do not think there is an official schedule with this level..."
- "Isn't it odd that these fringe science / medical theories are so often championed by practitioners..."
- "Would you please email your email address to me: firstname.lastname@example.org (I think?) I sent..."
- Young Muslim thrillseekers won't find Paradise in Syria
- SanDisk says new SSDs will be price competitive against legacy hard drives
- State regulations for tanning beds not enough: A national regulatory framework is needed
- Hallucinations and delusions more common than thought
- Are antidepressants more effective than assumed?