There has long been a hypothesis that a starvation diet can extend lifespan.
The only way it was really shown was by weaning mice on such a diet - and that isn't really ethical for human babies. And it doesn't work in the wild, because dietary restriction compromises the immune system’s ability to fight off disease and reduces the muscle strength necessary to flee a predator. Most animals don't live long enough to catch 'old age' diseases like cancer and the late-life pathologies that humans do.
A new paper in BioEssays also finds that consuming a diet very low in nutrients can extend lifespan in laboratory animals. Some studies have found that severely restricted food intake reduces the incidence of diseases of old age, such as cancer, which leads to extrapolations about the increase in lifespan. Despite cancer in 3,000 year old skeletons, the notion that cancer is caused by the modern lifestyle persists. The fact remains that the longer you stay alive, the more your chances of cancer increase.
“This effect has been demonstrated in laboratories around the world, in species ranging from yeast to flies to mice. There is also some evidence that it occurs in primates,” says lead author, Dr, Margo Adler, an evolutionary biologist at UNSW Australia. “But we think that lifespan extension from dietary restriction is more likely to be a laboratory artefact.
Dietary restriction also leads to increased rates of cellular recycling and repair mechanisms in the body, says Adler.
The new hypothesis is that this effect evolved to help animals continue to reproduce when food is scarce; they require less food to survive because stored nutrients in the cells can be recycled and reused. It is this effect that could account for the increased lifespan of laboratory animals on very low-nutrient diets, because increased cellular recycling reduces deterioration and the risk of cancer.
“This is the most intriguing aspect, from a human health stand point. Although extended lifespan may simply be a side effect of dietary restriction, a better understanding of these cellular recycling mechanisms that drive the effect may hold the promise of longer, healthier lives for humans,” Adler says.
It may be possible in future, for example, to develop drugs that mimic this effect.
Citation: M. I. Adler, R. Bonduriansky, ‘Why do the well-fed appear to die young?’ BioEssays, DOI: 10.1002/bies.201300165.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Questions a Surface Pro 3 user has about Windows 10.
- Ice Loss Due To Warming Is Even Changing Gravity
- Top Mass: CMS Again On Top!
- Sterile Neutrinos Remain Elusive
- The Enemy Of Archaeology Is Not People, It's Salt
- Publish, Blog, Tweet: Furthering One's Career In Science Today
- Sharks Have Personalities
- "Validating my ethical concerns about this paper, the NIH version now has the following disclaimer..."
- "While demonstrating the versatility of the 555, in this case using it as a Schmitt trigger by shorting..."
- "I'm not sure why you are so focused on longevity. It is not unheard of for some ancient persons..."
- "Yeah. I think they decided to go with Windows 10 just to shake up people who were waiting..."
- "And of course one of the saddest things about this negative attitude among the public is that support..."
- New study finds link between depression and abnormal brain response to visceral pain in patients with IBS
- HHS releases 13th Report on Carcinogens
- Common painkillers combined with other drugs may cause high risk of GI bleeding
- Dog's epigenome gives clues to human cancer
- Horizon Report urges schools to tackle 'wicked' digital skills challenge