Writing in the Journal of Biological Chemistry, a group of researchers found that nutrient deprivation of neurons produced sex-dependent effects. Male neurons more readily withered up and died, while female neurons did their best to conserve energy and stay alive.
That's right, nature has declared female brains should survive with a lot less than males. Take that, glass ceiling!
The idea that the sexes respond differently to nutrient deprivation is not new and revolves around the male preferences to conserve protein and female preferences to conserve fat. However, these metabolic differences have really only been examined in nutrient-rich tissues like muscles, fat deposits, and the liver.
Robert Clark and colleagues at the Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center examined whether this sex-dependent response in starvation could manifest in brain cells. They grew neurons taken separately from male and female rats or mice in lab dishes and subjected them to starvation over 72 hours.
After 24 hours, the male neurons experienced significantly more cell dysfunction (measured by analyzing cell respiration, which decreased by over 70% in male cells compared to 50% in female cells) and death. Visually, male neurons also displayed more abundant signs of autophagy, whereby a cell breaks down its components as a fuel source, while female neurons created more lipid droplets to store fat reserves.
As with other cell culture studies, the researchers note these results may not be truly indicative of what happens in living animals during starvation, but it allows them to look at the neurons independent of external factors like circulating hormones.
Article: "Starving Neurons Show Sex Difference in Autophagy" by Lina Du, Robert W. Hickey, Hülya Bayır, Simon C. Watkins, Vladimir Tyurin, Fengli Guo, Patrick M. Kochanek, Larry W. Jenkins, Jin Ren, Greg Gibson, Charleen T. Chu, Valerian E. Kagan, and Robert S. B. Clark, J. Biol. Chem..2009; 284: 2383-2396
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Most Idiotic Rejection Of Course From Philosopher Of Science Not Grasping Relativity
- Lettuces Now, What Next - Could Astronauts Get All Their Oxygen And Food From Algae Or Plants?
- An Argument For Legalizing Doping In Sports
- Innate GMO Potato Deregulated By USDA
- An Historical Moment For Diabetes
- Two Saturdays: Why A 4 Day Work Week Might Make Sense
- College Students Know E-cigarettes Aren't Tobacco, Their Professors Are More Confused
- "There is no shortage of technology to 'feed the world' but Fedoroff's techno-optimist fantasy illogically..."
- "The FDA can not approve needed drugs and approves un-needed drugs. One more argument that drug..."
- "Just adding a thought here. This is to do with the idea of adapting BIOS-3 and also crop growing..."
- "I'll take this with a grain for now..."
- "They even bought off the nongmo project and convinced cereal companies to add poison to get us..."
- Why girls are less interested in computer science: Classrooms are too 'geeky'
- Frogs make irrational choices - and what means for understanding animal mating
- Depression, blood pressure extremes predict highest rates of vascular events
- The Superhero craze may be over
- Where bread began: Ancient tools used to reconstruct (and eat) prehistoric cuisine