When it comes to gambling, many millions of people just don't know when to walk away. The behavior can take a tremendous toll on their finances and family life, and currently available treatments are often associated with extremely high relapse rates.
According to new research presented at the annual meeting of the American College of Neuropsychopharmacology (ACNP), however, there may be alternative and surprisingly simple treatments available for gambling addicts--medications that decrease urges and increase inhibitions. In other words, medications often used to treat drug abuse.
University of Minnesota scientists used tasks that measure cognition to identify what motivates the extreme gambling behavior. They enrolled men and women with a primary diagnosis of pathological gambling in one of three medication studies. Study sites varied in size from 70 to 100 participants.
The researchers sought to understand how gamblers decide whether or not to bet by focusing on two brain processes: urge and inhibition. In order to group individuals into categories that address differences in their biology, scientists separated pathological gamblers into two major subtypes: gamblers who are driven by urge (i.e., individuals who report gambling when the desire becomes too strong to control), and those who do not show normal inhibition of impulsive behaviors (i.e., individuals who report being unable to restrict behaviors even when urges are minimal or virtually non-existent).
In the first subtype, gamblers who are driven by urge responded well to treatment with medications that block the brain opioid system (e.g., naltrexone) or certain receptors for the neurotransmitter glutamate (e.g., memantine). The research team also found that family history plays an important role in refining this group even further. People with a family history of addiction responded even better to the opioid blocker, which has been shown in other studies to decrease the urge to use substances such as alcohol.
The second subtype, gamblers who have difficulty inhibiting their behaviors and react to the smallest desires, respond well to medications that act on a specific enzyme, catechol-O-methyl-transferase (COMT), which plays a major role in the function of the prefrontal cortex. Researchers found that decreasing the function of COMT can increase one's ability to inhibit their desire to gamble.
"By understanding these different subtypes, we are able to target the core biology of the illness with individualized treatment," said Jon Grant, MD, JD, MPH, Associate Professor of Psychiatry at the University of Minnesota and ACNP member.
"When we look at pathological gambling as an addiction and try to understand the sense of urges and inhibitions, we are able to target the treatment with medication more effectively."
Grant cautioned that while these results are exciting and a majority of people respond to these medications, there are still some for whom these medications do not work. Additional research is needed to further refine the subtypes.
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