If you are obese, it is reasonably well-established that you are not going to exercise and vibration machines that sound like they might be less work, like the kind developed by the Soviets for astronauts, actually can burn through 400 calories in 15 minutes, so they are not for the casual - but a recent study found that low-intensity vibrations led to improvements in the immune function of obese mice.
If the same effect can be found in people, it would have clinical benefits for obese people suffering from a wide range of immune problems related to obesity.
To make this discovery, researchers fed a group of adult mice a high fat diet for seven months to make them obese. At the end of this first phase of the experiment, the damage to the immune and skeletal systems of the obese mice was significant, decreasing B- and T-cell populations in the blood, and markedly accelerating the loss of bone.
The second phase began after the mice were obese relative to regular controls, with the creation of a sub-group that was subjected to daily 15-minute bouts of low-intensity vibration, barely perceptible to human touch. Results showed that the vibration intervention helped to rescue both the immune and skeletal systems, returning them toward outcomes measured in mice that were fed a regular diet.
The study provides evidence that obesity markedly reduces the production of B- and T-cells and that brief daily exposure to low magnitude mechanical signals rescues B- and T-cell populations, even in a mouse that is already obese.
"This study demonstrates that mechanical signals can help restore an immune system compromised by obesity," said Clinton Rubin, Ph.D., study author from the Department of Biomedical Engineering at Stony Brook University in Stony Brook, New York. "While it is well known that obesity can cripple many physiologic systems, this work suggests that mechanical signals—in the absence of drugs—can help combat this disease and its sequelae. That these mechanical signals are so brief, and so mild, is further evidence of how exquisitely tuned our body is to external signals, and that remaining active—climbing stairs at work, taking a walk at lunch, standing while reading a book—will help achieve and retain good health. Stand up!"
Published in The FASEB Journal