Children suffer from the consequences of maternal drug exposure during pregnancy and Cannabis is one of the most frequently used substances.

A new study was done using mice and human brain tissue to decipher the molecular basis of how the major psychoactive component from Cannabis called delta-9-tetrahydrocannabinol or THC affects brain development of the unborn fetus. 

The study highlights that consuming Cannabis during pregnancy clearly results in defective development of nerve cells of the cerebral cortex, the part of the brain that orchestrates higher cognitive functions and drives memory formation. In particular, THC negatively impacts if and how the structural platform and conduit for communication between nerve cells, the synapses and axons, will develop and function.

The researchers also identified Stathmin-2 as a key protein target for THC action, and its loss is characterized as a reason for erroneous nerve growth. It is stressed that Cannabis exposure in experimental models precisely coincided with the fetal period when nerve cells form connections amongst each other.

According to Professor Tibor Harkany of Karolinska Institutet and Medical University Vienna in Austria, these developmental deficits may evoke life-long modifications to the brain function of those affected. Even though not all children who have been exposed to Cannabis will suffer immediate and obvious deficits, Harkany warns that relatively subtle damage can significantly increase the risk of delayed neuropsychiatric diseases. 

"Even if THC only would cause small changes its effect may well be sufficient to sensitize the brain to later stressors or diseases to provoke neuropsychiatric illnesses in those affected in the future," says Harkany. "This concerns also the medical use of Cannabis, which should be avoided during pregnancy."



Published in the EMBO Journal.
Source: Karolinska Institutet