In a new study, cancer biologists show that restoring the protein p53's function in mice with early lung cancer has no effect in tumor development but restoring p53 function later may prevent more advanced tumors from spreading throughout the body.
Cancer researchers have known since the 1980s that p53 plays a critical role in protecting cells from becoming cancerous and P53 is defective in about half of all human cancers; when it functions correctly, it appears to suppress tumor formation by preventing cells with cancer-promoting mutations from reproducing. Knowing p53's critical role in controlling cancer, researchers have been trying to develop drugs that restore the protein's function, in hopes of reestablishing the ability to suppress tumor growth. One such drug is now in clinical trials.
P53 is known to control the cell cycle, which regulates cell division. In particular, the protein stops a cell from dividing when its DNA is damaged. P53 then activates DNA repair systems, and if the damage proves irreparable, it instructs the cell to commit suicide.
Without p53, cells can continue dividing even after acquiring hazardous mutations. Eventually, after a cell accumulates enough mutations, it becomes cancerous. Cancer biologists believe that sustained inactivation of p53 and other tumor suppressors is necessary for cancers to become advanced.
The findings of this new study suggest that drugs that restore p53 function could help prevent aggressive lung cancers from metastasizing, though they might spare benign tumor cells that could later turn aggressive. "Even if you clear the malignant cells, you're still left with benign cells harboring the p53 mutation," says David Feldser, lead author of the paper and a postdoctoral fellow at the David H. Koch Institute for Integrative Cancer Research at MIT.
However, such drugs are still worth pursuing because they could prolong the life of the patient, says Feldser, who works in the lab of Koch Institute Director Tyler Jacks, senior author of the paper.
In the new study, the researchers studied mice that are genetically engineered to develop lung tumors shortly after birth. Those mice also have an inactive form of the p53 gene, but the gene includes a genetic "switch" that allows the researchers to turn it back on after tumors develop.
At first, the researchers turned on p53 in mice that were four weeks old and had developed tumors known as adenomas, which are benign. To their surprise, restoring p53 had no effect on the tumors.
Next they turned on p53 in another group of tumor-prone mice, but they waited until the mice were 10 weeks old. At this point, their tumors had progressed to adenocarcinomas, a malignant type of cancer. In these mice, turning on p53 cleared the malignant cells, but left behind cells that had not become malignant.
This suggests that the p53 signaling pathway is recruited only when there is a lot of activity from other cancer genes. In benign tumors, there is not enough activity to engage the p53 system, so restoring it has no effect on those tumors. In the malignant tumor cells, reactivated p53 eliminates cells with too much activity in a signaling pathway involving mitogen-activated protein kinase (MAPK), which is often overactive in cancer cells, leading to uncontrolled growth.
The researchers are now looking for drugs that reactivate mutant forms of p53, and also plan to study whether tumors that have metastasized would be vulnerable to p53 restoration.
The research was funded by the Howard Hughes Medical Institute.
Citation: David M. Feldser, Kamena K. Kostova, Monte M. Winslow, Sarah E. Taylor, Chris Cashman, Charles A. Whittaker, Francisco J. Sanchez-Rivera, Rebecca Resnick, Roderick Bronson, Michael T. Hemann, et al., 'Stage-specific sensitivity to p53 restoration during lung cancer progression', Nature 468, 572-575 (24 November 2010) doi:10.1038/nature09535
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Suggestion: The EM Drive Is Getting The Appropriate Level Of Attention From The Science Community
- It's Naive To Pretend Differences Between Women And Men Are Just Genetics
- Bang! Meet The Highest-Energy Hadron Collision Ever Imaged!
- Will Aspartame Critics Now Be Less Bitter?
- GMOs Have Formaldehyde? Bizarre Claim Challenged By Experts
- New Results From The LHC At 13 TeV!
- Bees: Activists Remain Silent While This Pollinator Killer Decimates Millions
- "Just one question: those two jets...And the issue of rare statistics...Perhaps you could post some..."
- "Thanks, glad my article helped...."
- "Oh, silly me, I meant to write divided by the wavelength. Sometimes I come out with the wrong words..."
- "Yes, well caught, I got it upside down when I corrected it last night, fixed now :)...."
- "Excellent article. Thank you for the objective analysis that so few journalists treat this subject..."
- Environmental activists are ignoring the real bee killer
- Corporate leader’s science creds under attack
- Rare bacteria cause outbreak in NYC
- John Stossel rips the EPA and NRDC too. Because they’re practically the same thing
- Fact checking pHony water
- Hopewell NJ votes gas pipeline off the island; why not shut down your entire energy supply to save Mother Earth?
- How bees naturally vaccinate their babies
- Mild hypothermia in deceased organ donors improves organ function in kidney transplant
- Trying to quit smoking? First strengthen self-control
- Paralyzed men move legs thanks to non-invasive spinal cord stimulation
- California 'rain debt' equal to average full year of precipitation