Our daily lives are filled with changes that force us to abandon old behavioral strategies and develop new, more appropriate responses. While it is clear that new rules are often deduced through trial-and-error learning, the neural dynamics that underlie the change are not well understood.

A study in Neuron has uncovered new information about the neural dynamics of developing new problem solving strategies. The research supports the idea of "a-ha" moments in the brain that are associated with sudden insight, the authors say.

"The ability of animals and humans to infer and apply new rules in order to maximize reward relies critically on the frontal lobes," explains one of the researchers who led the study, Dr. Jeremy K. Seamans from the Brain Research Center at the University of British Columbia (UBC) and Vancouver Coastal Health Research Institute. "In our study, we examined how groups of frontal cortex neurons in rat brains switch from encoding a familiar rule to a completely novel rule that could only be deduced through trial and error."

Specifically, researchers were interested in determining whether networks of neurons change their activity in a slow gradual way as an old strategy is abandoned and a new one is learned or whether there is a more abrupt transition.

Using sophisticated statistical techniques to study ensembles of neurons in the medial frontal cortex on a trial-by-trial basis as rats deduced a novel rule in a specially designed task, they found that the same populations of neurons formed unique network states that corresponded to familiar and novel rules. Interestingly, although it took many trials for the animals to figure out the new rule, the recorded ensembles did not change gradually but instead exhibited a rather abrupt transition to a new pattern that corresponded directly to the shift in behavior, as if the network had experienced an "a-ha" moment.

Taken together, these findings provide concrete support for sudden transitions between neural states rather than slow, gradual changes. "In the present problem solving context where the animal had to infer a new rule by accumulating evidence through trial and error, such sudden neural and behavioral transitions may correspond to moments of 'sudden insight,'" concludes Dr. Durstewitz.


Citation: Seamans et al., 'Abrupt Transitions between Prefrontal Neural Ensemble States Accompany Behavioral Transitions during Rule Learning', Neuron, 66, 438-448, May 2010; doi:10.1016/j.neuron.2010.03.029