Triclosan, an antibacterial chemical widely used in hand soaps and other personal-care products, may impair muscle function. It hinders muscle contractions at a cellular level, slows swimming in fish and reduces muscular strength in mice, according to research from the University of California, Davis, and the University of Colorado.
Triclosan is commonly found in antibacterial products like hand soaps and deodorants, mouthwashes, toothpaste, bedding, clothes, carpets, toys and trash bags. The U.S. Environmental Protection Agency in 1998 estimated that more than 1 million pounds of triclosan are produced annually in the United States and that the chemical is detectable in waterways and aquatic organisms ranging from algae to fish to dolphins, as well as in human urine, blood and breast milk.
Triclosan was first developed to prevent bacterial infections in hospitals but since then its use among concerned parents has become widespread in home antibacterial products. But the U.S. Food and Drug Administration (FDA) says that outside use in some toothpastes to prevent gingivitis, there is no evidence that triclosan provides other health benefits or that antibacterial soaps and body washes are more effective than regular soap and water. Experts also express concern about the possibility of resistant bacterial strains developing with the overuse of antibacterial products.
The hygiene hypothesis contends that kids may be getting sick more because we protect them from too much. Basically, they need to play in the dirt more and have helicoptering parenting less.
A scraped knee does not need triage and it's not brain surgery. Not everything needs to be vaporized with chemicals. Credit: Shutterstock
The investigators performed several experiments to evaluate the effects of triclosan on muscle activity, using doses similar to those that people and animals may be exposed to during everyday life. In test tube experiments, triclosan impaired the ability of isolated heart muscle cells and skeletal muscle fibers to contract. Specifically, the team evaluated the effects of triclosan on molecular channels in muscle cells that control the flow of calcium ions, creating muscle contractions. Normally, electrical stimulation (“excitation”) of isolated muscle fibers under experimental conditions evokes a muscle contraction, a phenomenon known as “excitation-contraction coupling” (ECC), the fundamental basis of any muscle movement, including heartbeats. But in the presence of triclosan, the normal communication between two proteins that function as calcium channels was impaired, causing skeletal and cardiac muscle failure.
“Triclosan is found in virtually everyone’s home and is pervasive in the environment,” said Isaac Pessah, professor and chair of the Department of Molecular Biosciences in the U.C. Davis School of Veterinary Medicine and principal investigator of the study. “These findings provide strong evidence that the chemical is of concern to both human and environmental health.”
The team also found that triclosan impairs heart and skeletal muscle contractility in living animals. Anesthetized mice had up to a 25-percent reduction in heart function measures within 20 minutes of exposure to the chemical.
“The effects of triclosan on cardiac function were really dramatic,” said co-author Nipavan Chiamvimonvat, professor of cardiovascular medicine at UC Davis. “Although triclosan is not regulated as a drug, this compound acts like a potent cardiac depressant in our models.”
In addition, the mice had an 18-percent reduction in grip strength for up to 60 minutes after being given a single dose of triclosan. Grip strength is a widely used measure of mouse limb strength, employed to investigate the effects of drugs and neuromuscular disorders.
Finally, the investigators looked at the effects of triclosan exposure on fathead minnows, a small fish commonly used as a model organism for studying the potential impacts of aquatic pollutants. Those exposed to triclosan in the water for seven days had significantly reduced swimming activity compared to controls during both normal swimming and swim tests designed to imitate fish being threatened by a predator.
“We were surprised by the large degree to which muscle activity was impaired in very different organisms and in both cardiac and skeletal muscle,” said co-author Bruce Hammock, professor in the UC Davis Department of Entomology. “You can imagine in animals that depend so totally on muscle activity that even a 10-percent reduction in ability can make a real difference in their survival.”
Chiamvimonvat cautioned that translating results from animal models to humans is a large step and would require further study. However, the fact that the effects were so striking in several animal models under different experimental conditions provides strong evidence that triclosan could have effects on animal and human health at current levels of exposure.
“In patients with underlying heart failure, triclosan could have significant effects because it is so widely used,” Chiamvimonvat said. “However, without additional studies, it would be difficult for a physician to distinguish between natural disease progression and an environmental factor such as triclosan.”
Pessah questioned arguments that triclosan, introduced more than 40 years ago, is safe partly because it binds to blood proteins, making it not biologically available. Although triclosan may bind to proteins in the blood, that may not necessarily make the chemical inactive, he said, and actually may facilitate its transport to critical organs. In addition, some of the current experiments were carried out in the presence of blood proteins, and disrupted muscle activity still occurred.
Because the chemical structure of triclosan resembles other toxic chemicals that persist in the environment, the FDA and the U.S. Environmental Protection Agency are conducting new risk assessments of the chemical. Based on their study outcomes, the researchers argue that the potential health risks call for greater restrictions.
“We have shown that triclosan potently impairs muscle functions by interfering with signaling between two proteins that are of fundamental importance to life,” said Pessah. “Regulatory agencies should definitely be reconsidering whether it should be allowed in consumer products.”
Said Hammock: “Triclosan can be useful in some instances, however it has become a ubiquitous ‘value added’ marketing factor that actually could be more harmful than helpful. At the very least, our findings call for a dramatic reduction in its use.”
Published in the Proceedings of the National Academy of Sciences.
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