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    Uncharacterized Genes: Evolutionary Rates And A Clue
    By News Staff | February 9th 2013 12:02 PM | Print | E-mail | Track Comments

    Humans have an unclear number of genes - ab initio gene finding and comparative gene finding yield different totals (see the Human Genome Project for details) - but it is likely in the low 20,000s and those genes make nearly as many proteins. The functions of most genes have not been fully determined, but knowing what a particular gene does could obviously help researchers understand disease processes and identify targets for new drugs. 

     A new paper says genes that have roles in the same biological pathways change their rate of evolution in parallel, a finding that could be used to discover their functions. The researchers studied the evolving genomes of 18 yeast species and 22 mammalian species, looking particularly at genes that are involved in meiosis cell division and in DNA repair. They found parallel changes, such as acceleration or deceleration, in evolutionary rates among not only genes encoding proteins that physically interact with each other, but also among those that had no direct contact but still participated in meiosis or DNA repair pathways.

    All genes mutate over time, which can be beneficial, harmful or meaningless. Some yeast species evolved a different method of reproduction and meiosis stopped as it was no longer essential for survival. Through subsequent generations, the rate of change in the genes involved in making meiosis proteins accelerated, leading to deterioration of the unnecessary DNA sequences.

    "For our study, we took a close look at the way genes evolved between species and we found an interesting signature," said

    lead investigator Nathan Clark, Ph.D., assistant professor of computational and systems biology at the Pitt School of Medicine

    in their statement. "Genes that perform biological functions together have similar evolutionary histories in that the rates at which they change parallel each other. This could allow us to identify partner genes that we might never have suspected to work together in biochemical pathways.

     A key question is: How important is that gene at that time? If a species encounters a new challenge in its environment, the genes associated with it might have to evolve through subsequent generations in order to adapt that important pathway and ensure species survival."

    By tracking those complementary rate changes, it could be possible to identify which genes participate in the same important pathways, providing clues to their function.

    "In the future, a researcher studying a particular disease process might be able to plug in a couple of known genes in a database of evolutionary rate changes to find others that have a parallel history," Clark said. "That could provide new insight into the workings of the biological pathway of interest."


    Citation: Nathan L. Clark, Eric Alani, and Charles F. Aquadro, 'Evolutionary Rate Covariation in Meiotic Proteins Results from Fluctuating Evolutionary Pressure in Yeasts and Mammals', Genetics February 2013 193:529-538; published ahead of print November 26, 2012, doi:10.1534/genetics.112.145979