XBiotech, a company involved in commercializing biological therapies, has published the results from its Phase I/II oncology study conducted at MD Anderson Cancer Center in Houston.
The study describes the outcome in 52 advanced cancer patients treated with their Xilonix™ non-cytotoxic, anti-tumor therapy. The so-called true human antibody therapy was reported to have an excellent safety profile and the report describes comprehensive measures of patient performance during therapy with Xilonix.
It was reported that overall, patients constitutional symptoms improved, including reduction in pain and fatigue. A highlight of the report was the finding that almost two-thirds of patients assessed with a new form of X-ray imaging demonstrated physical recovery of lean body mass (which is another way of referring to muscle mass) but moreover, that these same patients had dramatic improvement in overall survival.
The Company's lead product candidate, in Phase III clinical studies, is a novel, breakthrough treatment for advanced colorectal cancer
In an accompanying commentary, Dr. Charles Dinarello wrote, "The study is a unique contribution because it opens entire new areas in cancer therapeutics. The study also provides a rationale for early use of anti-cytokine therapy in cancer and sets the stage for use of anti-cytokine treatment in combination with kinase inhibitors and antiimmunosuppressive treatments."
Chairman&CEO added, "We are certainly happy to see these very important findings recognized in the world's premier cancer journal. I hope the wider dissemination of this scientific and clinical milestone helps drive the development of Xilonix therapy as well as others that work to control cancer using less toxic approaches."
Published in Lancet Oncology.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- How Gut Bacteria Ensure A Healthy Brain – and Could Play A Role In Treating Depression
- Researchers Created A Laser Bullet To See What It Would Look Like - And Here It Is
- The Strange Organic Molecules In Titan's Atmosphere
- We're Too Late To Prevent 137,000 More Ebola Cases, Says Epidemiology Paper
- The Quote Of The Week - Shocked And Disappointed
- ASTEROIDS Act: Who Owns Space?
- Type 1 Diabetes Surges In White Kids
- "Because there are only 2?..."
- "I found the AMO/PDO charts to be very broad, and hard to tell (at least with the limited knowledge..."
- "I have dabbled with AMO and PDO, but it really needs to be more of a comparison to SST's, at which..."
- "The UN with it's small direct Ebola budget is hiring Ebola survivors to take care of sick kids..."
- "Ebola patients are sometimes thought of as Zombies returning from the dead. If one is low in fluids..."
- How to sell a toxic pesticide the smart way–call it organic
- Leftist dystopia? Anti-technology fever animates opposition to GMOs and other ‘disruptive’ technologies
- CDC faced a nearly impossible balancing act with Ebola, and failed
- Why Chobani reversed course, making yoghurt only from milk from cows not fed GMO grain
- Monterey, California, hotbed of anti-GMO activism, home to new GMO corn farm
- Evolution is sometimes messy or even outright ridiculous