The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells. A study by UC Riverside biochemists that focuses on cancer cells reports that ingesting apigenin, a naturally occurring dietary agent found in vegetables and fruit , improves cancer cells' response to chemotherapy.
Xuan Liu, a professor of biochemistry, and Xin Cai, a postdoctoral researcher working in her lab, found that apigenin localizes tumor suppressor p53, a protein, in the cell nucleus – a necessary step for killing the cell that results in some tumor cells responding to chemotherapy.
The study in Proceedings of the National Academy of Sciences provides a novel approach to conquer tumor resistance to chemotherapy, and suggests an avenue for developing safe chemotherapy via naturally occurring agents.
Normally, cells have low levels of p53 diffused in their cytoplasm and nucleus. When DNA in the nucleus is damaged, p53 moves to the nucleus where it activates genes that stop cell growth and cause cell death. In this way, p53 ensures that cells with damaged DNA are killed.
In many cancers, p53 is rendered inactive by a process called cytoplasmic sequestration. Apigenin is able to activate p53 and transport it into the nucleus, resulting in a stop to cell growth and cell death.
"In therapy you want to kill cancer cells," explained Cai, the first author of the research paper. "But to stop cell growth and to kill the cell, p53 first needs to be moved to the cell's nucleus to function. Apigenin is very effective in localizing p53 this way."
Apigenin is mainly found in fruit (including apples, cherries, grapes), vegetables (including parsley, artichoke, basil, celery), nuts and plant-derived beverages (including tea and wine). It has been shown by researchers to have growth inhibitory properties in several cancer lines, including breast, colon, skin, thyroid and leukemia cells. It has also been shown to inhibit pancreatic cancer cell proliferation.
"Our study advocates the inclusion of vegetables and fruit in our daily diet to help prevent cancer," said Liu, the research paper's coauthor.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- 'Healthy' Fat Tissue Could Be Key To Reversing Type 2 Diabetes
- Fewer Wild Fish Needed: Genetically Modified Plants Produce Omega-3 Fish Oil
- Where Did The Missing BP Oil Go? The Gulf Of Mexico Floor
- 80 Percent Of Neurosurgeons Now Practice Defensive Medicine
- Prevent Alzheimer's Disease By Drinking Beer?
- Science 2.0: Can Large-Scale Analytics Predict Major Societal Events?
- Football Physics: The Science Of Deflategate
- "This is such an important article. Thank you! After reading the book, Teaming with Microbes: A..."
- "Why? Isn't it like saying 'I won't eat anything but wild strawberries'? If everyone adopted that..."
- "The problem is that women are more likely to compromise when they shouldn't. This may be because..."
- "The best state is Mississippi, which is poor, uneducated, religious and Republican, all things..."
- "Good news, if it can be made economically viable. For now, though, I still won't touch farmed fish...."