Viruses aren't just disease agents any more. Scientists now know they can be used in therapies for cancer but concerns over the safety of 'oncolytic viruses' remain because they can also damage healthy tissues.
But Mayo Clinic researchers say they have discovered a way of controlling the viruses behind potential cancer therapeutics by engineering the virus's genetic sequence, using microRNAs to restrict them to specific tissues. The microRNAs destabilize the virus's genome, making it impossible for the virus to run amok. The discovery is reported in the current issue of Nature Medicine.
MicroRNAs are the nucleotide snippets that are encoded by genes, but don't end up as proteins. In many cases, they have a role in down-regulating different cellular genes. In this case, a virus is engineered to be responsive to microRNAs that are present in certain cell types. Using this new form of targeting, researchers redirected a virus normally responsible for a lethal muscle infection to recognize only cancer cells. The laboratory mice that received the engineered virus were cured of established tumors and suffered no ill effects.
"Our findings demonstrate a new tool for molecular medicine that should also help allay concern over the use of viruses as a therapeutic delivery system," says Stephen Russell, M.D., Ph.D., Mayo physician-scientist and lead author of the study.
Significance of the research
Most viruses can infect different cell types, which leads to the array of symptoms during a viral infection. Now as viruses are being engineered for use as vaccines, cancer therapeutics and gene therapy vectors, researchers want to restrict and redirect the types of cells they do (or don't) infect as additional safeguards against disease. The target sequences of microRNAs used in the study kept the virus from destroying muscle cells while allowing viral replication to proceed in cancer cells allowing the virus to completely cure mice with melanoma.
The Mayo researchers say microRNA target insertion may be a new way to make viruses safer for use in cancer therapy and could lead to new methods of making safer vaccines.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Some Celiac Disease May Be Due To Viruses
- Pubic Hair Grooming Common Among Some US Women
- Out Of Africa: What They Do Not Tell Us
- How A Former Naturopath Can Help Unravel The Trickery of Alternative Medicine
- Brain Cancer: Why Glioblastoma Is So Difficult To Treat
- Little To No Association Between Butter Consumption And Chronic Disease Or Total Mortality
- Thinking 'I Can Do Better' Really Can Improve Performance, Study Finds
- " Some parts from my second response to Nina Teicholz article ( http://www.bmj.com/content/351/bmj..."
- "He's just a physicist, dabbling. PS: His second reference in no way is trying to say Neanderthal..."
- "Science researchers did the CARET study, to see if vitamin A could chemo-prevent lung cancer (it..."
- "Whether or not a conclusion can be used for bad purposes should never be the reason to shut down..."
- "This is a shockingly racist, repulsive, pseudoscientific article. It is so depressing to find it..."
- Study finds that plant growth responses to high carbon dioxide depend on symbiotic fungi
- Telomere length is indicator of blood count recovery in treatment of Acute Myeloid Leukemia
- Natural metabolite can suppress inflammation
- New technology helps ID aggressive early breast cancer
- US needs greater preparation for next severe public health threats, panel finds