Viruses aren't just disease agents any more. Scientists now know they can be used in therapies for cancer but concerns over the safety of 'oncolytic viruses' remain because they can also damage healthy tissues.
But Mayo Clinic researchers say they have discovered a way of controlling the viruses behind potential cancer therapeutics by engineering the virus's genetic sequence, using microRNAs to restrict them to specific tissues. The microRNAs destabilize the virus's genome, making it impossible for the virus to run amok. The discovery is reported in the current issue of Nature Medicine.
MicroRNAs are the nucleotide snippets that are encoded by genes, but don't end up as proteins. In many cases, they have a role in down-regulating different cellular genes. In this case, a virus is engineered to be responsive to microRNAs that are present in certain cell types. Using this new form of targeting, researchers redirected a virus normally responsible for a lethal muscle infection to recognize only cancer cells. The laboratory mice that received the engineered virus were cured of established tumors and suffered no ill effects.
"Our findings demonstrate a new tool for molecular medicine that should also help allay concern over the use of viruses as a therapeutic delivery system," says Stephen Russell, M.D., Ph.D., Mayo physician-scientist and lead author of the study.
Significance of the research
Most viruses can infect different cell types, which leads to the array of symptoms during a viral infection. Now as viruses are being engineered for use as vaccines, cancer therapeutics and gene therapy vectors, researchers want to restrict and redirect the types of cells they do (or don't) infect as additional safeguards against disease. The target sequences of microRNAs used in the study kept the virus from destroying muscle cells while allowing viral replication to proceed in cancer cells allowing the virus to completely cure mice with melanoma.
The Mayo researchers say microRNA target insertion may be a new way to make viruses safer for use in cancer therapy and could lead to new methods of making safer vaccines.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Should Pregnant Women Be Concerned About BPA?
- The Five Stages Of A Dying Theory
- Russian scientists increase DVD storage capacity million times
- Australopithecus Afarensis: ‘Lucy’ Was A Tree Climber?
- Neanderthals: Not So Dumb
- President Elect Trump - Why Climate Change Is No Longer A Political Issue Outside The US
- Jena's Roots In The Tree Of Life
- "It's okay, I'm fine with off topic posts :). Had some interesting comment threads that went way..."
- "Just to let you know, Daniel Dady, that web privacy is becoming an ever-scarcer commodity and that..."
- "First to say, that I grant Science20 rights to publish my articles here, but I do retain copyright..."
- "You claim to 'know' because of 'something you saw on the web', but do not allow us to cite 'something..."
- "There is lots of proof. This is why astronomers are totally sure it is nonsense, an article..."
- Five PM? Time for Breakfast!
- Include Aerobic Fitness in Physical Exams, Heart Association Recommends
- Female Vervet Monkeys Assault Males that Do Not Participate in Fights
- Vaginal Ring Effective for HIV Infection Prevention
- Winter is No Wonderland
- On Fitness & Longevity, Don't Be Misled By Health Hype Headlines