by Gurkiran Dhuga&Glen Pyle

The fight for equality between the sexes has undoubtedly made significant advances recently. But a new meta-analysis examining sex differences in treatment for cardiovascular risk factors presents a depressing snapshot of the current state of medicine. In fact, it suggests that in order to make progress, we may need to go all the way back to the beginning. Back to primary care.

A Primary Deficiency

By Gurkiran Dhuga and Glen Pyle

Throughout the last few decades health concerns related to air pollution have been rising. Despite this focus there has been little research on the impact of air pollution on specific health conditions and mortality, even though there is a strong association between air pollution and overall life expectancy. A global study lead by researchers in Germany outlines the detrimental changes air pollution can have on human life expectancy. One surprising finding of the study was that cardiovascular disease, and not respiratory conditions, are the primary cause of early death from air pollution.

How Bad is Air Pollution?

As the search for an effective COVID19 treatment goes on, one therapy keeps re-appearing in the headlines: hydroxychloroquine. Early, observational studies on the use of hydroxychloroquine to treat patients with COVID19 failed to show any real benefits of the drug. The ability of hydroxychloroquine to prevent the development of COVID19, however, remained largely untested. But a study on the effectiveness of hydroxychloroquine to prevent COVID19 has been published and the results are not what anyone was hoping for.

The Set-Up

The antimalarial drug hydroxychloroquine, touted as a miracle cure for COVID-19, appeared to have had it’s Titanic moment, at least according to a study published in the Lancet. The retrospective study analyzed the records of patients from 6 continents and found that not only was hydroxychloroquine not an effective treatment, its cardiac side effects were potentially dangerous. But this was just the tip of the iceberg, and the results were disastrous.

The Study

Co-authored by by Lauren Philippi, Department of Human Health and Nutritional Sciences, University of Guelph

In late December 2019 an outbreak of pneumonia cases arose in Wuhan, China. Patients presented with an acute respiratory illness linked to the 2019 Novel Coronavirus (COVID-19). COVID-19 is a betacoronavirus, similar to Human Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) coronaviruses. SARS and MERS both cause severe respiratory disease. Although COVID-19 is primarily considered a respiratory virus, there is a strong link to cardiovascular disease.

COVID-19 — by the numbers