So called "memristors" are an intriguing hot topic in electronics and nanotechnology, and highly controversial to boot. A certain type of memristor device was predicted to exist in 1971. Being perhaps a simple electrical component much like a resistor or capacitor, HP claimed to have discovered the missing memristor in 2008, except, "The Missing Memristor has Not been Found" [Nature Publishing Group’s Scientific Reports 5, 11657 (1215)]

A simple and provocative title – The Missing Memristor has Not been Found! This harsh admission of reality without sugar coating is the very title, and not of some opinion piece, but of a scientific paper published by the very same Nature Publishing Group that is criticized right away in that very paper:

 

Not only that the Theory of Everything cannot be reached by empirical science. Experiment cannot even decide which medium level theory is correct and who was supposedly wrong.

John Baez writes in "The Crackpot Index - A simple method for rating potentially revolutionary contributions to physics":

Cryptography aims to secure communication. Eve should not be able to eavesdrop on the communication between Alice and Bob. Quantum cryptography is 100% secure in as far as the physics is concerned. However, it is unsatisfying if this security is merely promised by a still new and even partially controversial theory. Who wants to trust their most important secrets to something that may be wrong?