The Tau Of Alzheimer's
    By Hank Campbell | November 12th 2012 02:31 PM | 2 comments | Print | E-mail | Track Comments
    The American public loves underdogs, the outlier or even outcast who defies convention and is proven right.

    Dr. Claude Wischik may be just that. He believes that a protein called tau, which forms twisted fibers known as tangles inside the brain cells of Alzheimer's patients, is largely responsible for driving the disease.

    His theory that goes against much of the scientific community, which has spent 20 years and billions of dollars of pharmaceutical investment on a different protein, beta amyloid, which forms sticky plaques in the brains of sufferers. But a string of experimental drugs designed to attack beta amyloid have failed recently in clinical trials, including two this summer from Eli Lilly &Co. and a partnership involving Pfizer Inc., Johnson&Johnson and Elan Corp. 

    Wischik sees this as tau's big moment. 

    An Outcast Among Peers Gains Traction on Alzheimer's Cure by Jeanne Whalen, Wall Street Journal


    From reading the link, I suspect both camps are wrong about Alzheimer's. Part of the problem is the focus on attempting to develop a lucrative drug before understanding the roots of the disease.
    Gerhard Adam
    Investors are the new "peer-review".  After all, we saw how much effort went into understanding Alzheimer's versus developing the drug by this statement.
    But TauRx didn't publish a full set of data from the trial, causing some skepticism among researchers. (Dr. Wischik says it didn't to protect the company's commercial interests).
    Nothing like good old scientific objectivity.
    With his passionate beliefs, Dr. Wischik admits he may be just as much a zealot about tau as he accuses others of being about beta amyloid. "I may be," he says. "In the end…it's down to the phase 3 trial."
    ...and thus we have the marriage between commercial interests and religous fervor.
    Mundus vult decipi