A recent theory of aging says that
caloric restriction may do the trick but the research is inconsistent; the mice in the most promising studies were weaned that way, something unlikely to happen in human children. New research says even those studies may not be entirely accurate and that for lean mice – and therefore lean humans, if prior mouse studies were to be taken at face value – caloric restrictions as an anti-aging strategy may be a pointless, frustrating and even dangerous exercise.
But for fat mice, dieting makes sense and will extend life, the researchers say. That goes for people as well.