Although anorexia nervosa is categorized as an eating disorder, it is not known whether there are alterations of the portions of the brain that regulate appetite.
Now, a new study finds that women with anorexia have distinct differences in the insulta – the specific part of the brain that is important for recognizing taste – according to a new study by University of Pittsburgh and University of California, San Diego researchers.
The study also implies that there may be differences in the processing of information related to self-awareness in recovering anorexics compared to those without the illness – findings that may lead to a better understanding of the cause of this serious and sometimes fatal mental disorder.
In the study led by Angela Wagner, M.D., University of Pittsburgh School of Medicine, and Walter H. Kaye, M.D., of the University of Pittsburgh and the University of California, San Diego (UCSD) Schools of Medicine, the brain activity of 32 women was measured using functional magnetic resonance imaging (fMRI.) The research team looked at images of the brains of 16 women who had recovered from anorexia nervosa – some of whom had been treated at the Center for Overcoming Problem Eating at Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center –and 16 control subjects. They measured their brains’ reactions to pleasant taste (sucrose) and neutral taste (distilled water.)
The results of the fMRI study are the first evidence that individuals with anorexia process taste in a different way than those without the eating disorder.
In response to both the sucrose and water, imaging results showed that women who had recovered from anorexia had significantly reduced response in the insula and related brain regions when compared to the control group. These areas of the brain recognize taste and judge how rewarding that taste is to the person. In addition, while the controls showed a strong relationship between how they judged the pleasantness of the taste and the activity of the insula, this relationship was not seen in those who had recovered from anorexia.
According to Kaye, it is possible that individuals with anorexia have difficulty recognizing taste, or responding to the pleasure associated with food. Because this region of the brain also contributes to emotional regulation, it may be that food is aversive, rather than rewarding. This could shed light on why individuals with anorexia avoid normally “pleasurable” foods, fail to appropriately respond to hunger and are able to lose so much weight.
“We know that the insula and the connected regions are thought to play an important role in interoceptive information, which determines how the individual senses the physiological condition of the entire body,” said Kaye. “Interoception has long been thought to be critical for self-awareness because it provides the link between thinking and mood, and the current body state.”
This lack of interoceptive awareness may contribute to other symptoms of anorexia nervosa such as distorted body image, lack of recognition of the symptoms of malnutrition and diminished motivation to change, according to Kaye.
Anorexia nervosa is a serious and potentially lethal illness, which may result in death in ten percent of cases. It is characterized by the relentless pursuit of thinness, emaciation and the obsessive fear of gaining weight. Anorexia commonly begins during adolescence, but strikes throughout the lifespan, and is nine times more common in females than in males. These characteristics support the possibility that biological processes contribute to developing this disorder.
Full article: Neuropsychopharmacology
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- What's Hiding Under The Clouds Of Venus - Heavy Metal Frost?
- Dopamine Receptor Agonist Drugs Linked To Gambling And Hypersexuality
- Ashes And Vegetables: The Diet Of Roman Gladiators Was Rather Poor
- Moderate Pot Use By Adolescents Doesn't Hurt IQ
- New Pill-only Regimens Cure Patients With Hardest-to-treat Hepatitis C Infection
- Manly Men And Feminine Women Are Not Evolutionary Mandates - They Are Urban Ones
- New Tractor Beam Can Repel And Attract
- "Since there's no actual link between vaccines and autism, I think the phrase Vaccines have been..."
- "I'll not argue that humanity made God in their image, because we sought to explain something we..."
- "I think we all are atheist, agnostics, and believers throughout our life time. I also, think some..."
- "The scenario mentioned above (Poor person shows up at emergency room with a fever... No health..."
- "Actually, I used to believe. It was what I was taught as a child and I was raised a Christian...."
- Mutagenesis: One way Europeans wish it was 1936 again
- Closer examination of risk factors for Latinos underscores cultural diversity
- Saving bees requires less pesticides, changing farming
- Could GM plants replace airport security scanners?
- In a battle of brains, chimpanzees match human toddlers
- ‘Urban farmers’ behind GMO labeling initiatives
- Alternate approach to traditional CPR saves lives
- Once CD8 T cells take on one virus, they'll fight others too
- 11 million will lose health insurance if ACA subsidies are eliminated, study finds
- Two Michigan high school students develop screening tools to detect lung and heart disease
- Even depressed people believe that life gets better