Anorexia nervosa and bulimia nervosa are psychological disorders characterized by extreme eating behavior and distorted body image – both have few proven effective treatments.
A new paper suggests that the altered function of neural circuitry contributes to restricted eating in anorexia and overeating in bulimia.
The study used functional MRI to test this neurocircuitry by measuring the brain response to sweet tastes in 28 women who had recovered from either anorexia or bulimia.
Relative to a cohort of 14 women who had never suffered from either disorder, those recovered from anorexia had significantly diminished, and those recovered from bulimia, significantly elevated responses to the taste of sucrose in the right anterior insula.
“It has been unknown whether individuals with anorexia or bulimia have a disturbance in the system that regulates appetite in the brain, or whether eating behavior is driven by other phenomena, such as an obsessional preoccupation with body image,” said Walter H. Kaye, MD, professor of psychiatry at the University of California, San Diego School of Medicine. “However, this study confirms earlier studies by our group and others that establish a clear link between these disorders and neural processes in the insula, an area of the brain where taste is sensed and integrated with reward to help determine whether an individual hungry or full.”
“One possibility is that restricted eating and weight loss occurs in anorexia because the brain fails to accurately recognize hunger signals,” said Oberndorfer. “Alternately, overeating in bulimia could represent an exaggerated perception of hunger signals.”
A recent complementary study that investigated brain structure in anorexia and bulimia nervosa (Frank et al 2013) similarly highlights that the insula could be an integral part of eating disorder pathology.
“It may be possible to modulate the experience by, for example, enhancing insula activity in individuals with anorexia or dampening the exaggerated or unstable response to food in those with bulimia,” said Kaye. Studies indicate that healthy subjects can use real-time fMRI, biofeedback or mindfulness training to alter the brain’s response to food stimuli. For patients with anorexia who have an overly active satiety signal in response to palatable foods, the researchers suggest bland or even slightly aversive foods might prevent the brain’s overstimulation. Medications may also be found that enhance the reward response to food, or decrease inhibition to food consumption in the brain’s reward circuitry.
This study was supported in part by grants from the National Institute of Mental Health and by the Price Foundation.
Published in the American Journal of Psychiatry. Additional contributors to the study include Guido K.W. Frank, MD; Alan N. Simmons, PhD; Angela Wagner, MD, PhD; Danyale McCurdy, PhD; Julie L. Fudge, MD; Tony T. Yang, MD, PhD; and Martin P. Paulus, MD.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Part II: Bee Deaths And CCD - Flawed Chensheng Lu Harvard Studies Endanger Bees
- Bitcoin And Anonymity: User's Identity Can Be Revealed Much Easier Than Thought
- Not Neonics: Parasites Are Bad For Honey Bees
- Violence, Sex And Taboo: The Original Brothers Grimm Fairy Tales Back In Print
- Volunteer-Based Peer Review: A Success
- Diversity Fatigue: Why Businesses Struggle To Close The Gender Gap
- "Which papers? Did I miss something? It seemed like your claim was based on those two papers (Lu..."
- "Pike squares, infantry squares, and other tactical formations are obsolete, but phalanxes and testudo..."
- "Revolutions are not funded by their own government. If it were a revolution, investment in the..."
- "Artificial gravity by radial acceleration doesn't need any testing. Every child has tested hurling..."
- "The control hives didn't have nicotine. I wonder if bees in North Carolina have higher susceptibility..."
- More public health interventions required to tackle grim reaper of 'lifestyle' diseases
- Saving ovaries does not help prevent prolapse for women after menopause
- Minimally invasive disc surgery is a pain in the neck
- Brain researchers pinpoint gateway to human memory
- The influence of the Isthmus of Panama in the evolution of freshwater shrimps in America