Anorexia nervosa and bulimia nervosa are psychological disorders characterized by extreme eating behavior and distorted body image – both have few proven effective treatments.
A new paper suggests that the altered function of neural circuitry contributes to restricted eating in anorexia and overeating in bulimia.
The study used functional MRI to test this neurocircuitry by measuring the brain response to sweet tastes in 28 women who had recovered from either anorexia or bulimia.
Relative to a cohort of 14 women who had never suffered from either disorder, those recovered from anorexia had significantly diminished, and those recovered from bulimia, significantly elevated responses to the taste of sucrose in the right anterior insula.
“It has been unknown whether individuals with anorexia or bulimia have a disturbance in the system that regulates appetite in the brain, or whether eating behavior is driven by other phenomena, such as an obsessional preoccupation with body image,” said Walter H. Kaye, MD, professor of psychiatry at the University of California, San Diego School of Medicine. “However, this study confirms earlier studies by our group and others that establish a clear link between these disorders and neural processes in the insula, an area of the brain where taste is sensed and integrated with reward to help determine whether an individual hungry or full.”
“One possibility is that restricted eating and weight loss occurs in anorexia because the brain fails to accurately recognize hunger signals,” said Oberndorfer. “Alternately, overeating in bulimia could represent an exaggerated perception of hunger signals.”
A recent complementary study that investigated brain structure in anorexia and bulimia nervosa (Frank et al 2013) similarly highlights that the insula could be an integral part of eating disorder pathology.
“It may be possible to modulate the experience by, for example, enhancing insula activity in individuals with anorexia or dampening the exaggerated or unstable response to food in those with bulimia,” said Kaye. Studies indicate that healthy subjects can use real-time fMRI, biofeedback or mindfulness training to alter the brain’s response to food stimuli. For patients with anorexia who have an overly active satiety signal in response to palatable foods, the researchers suggest bland or even slightly aversive foods might prevent the brain’s overstimulation. Medications may also be found that enhance the reward response to food, or decrease inhibition to food consumption in the brain’s reward circuitry.
This study was supported in part by grants from the National Institute of Mental Health and by the Price Foundation.
Published in the American Journal of Psychiatry. Additional contributors to the study include Guido K.W. Frank, MD; Alan N. Simmons, PhD; Angela Wagner, MD, PhD; Danyale McCurdy, PhD; Julie L. Fudge, MD; Tony T. Yang, MD, PhD; and Martin P. Paulus, MD.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Why An Extra Planet Can't Be Hidden Behind The Sun Or Above The South Pole
- The World Is Not Going To End A Few Hours From Now! AWFUL "Silly Season" Story In Telegraph
- Why Has Organic Farming Flatlined?
- Apollo Astronauts And Cardiovascular-Related Deaths
- My Applied National Security Paper. Being President Isn't For Idiots.
- The Daily Physics Problem - 5
- SYRINA: A Trojan Horse For Endocrine Disrupting Chemicals?
- "This is just AWFUL - the worst case of irresponsible journalism I have ever seen. An article in..."
- "Zoran:I didn't say I can't see any bearing. Instead, I unequivocally said Nothing you have written..."
- "Sorry for perhaps being not clear again: I always revise stuff if I find out that I have written..."
- "Essentially you are saying Mark these Nobel Laureates are wrong and you are right. This is commendable..."
- "So what was the precipitating event which caused your re-evaluation?..."
- Lattice structure absorbs vibrations
- Researchers pinpoint abrupt onset of modern day Indian Ocean monsoon system
- The discovery of new emission lines from highly charged heavy ions
- Molecular troublemakers instead of antibiotics?
- A research project coordinated by UC3M helps reduce the cost of parallel computing