Recent meta-analyses of the efficacy of second-generation antidepressants for youth have concluded that they possess anadvantage over placebo in terms of clinician-rated depressive symptoms, but no meta-analysis has included measures of quality of life, global mental health, self-esteem, or autonomy. Prior meta-analyses also did not include self-reports of depressive symptoms.
A recent article published in Psychotherapy and Psychosomatics reviewed the literature to understand the effects of antidepressant drugs on well-being in children and adolescents.
Results showed a non-significant difference between second-generation antidepressants and placebo in terms of self-reported depressive symptoms. Further, pooled across measures of quality of life, global mental health, self-esteem, and autonomy, antidepressants yielded no significant advantage over placebo.
Even though limited by a small number of trials, this analysis suggests that antidepressants offer little to no benefit in improving overall well-being among depressed children and adolescents.
The studies were selected through searching Medline, PsycINFO, and the Cochrane Central Register for Controlled Trials databases as well as GlaxoSmithKline's online trial registry, including self-reports of depressive symptoms and pooled measures of quality of life, global mental health, self-esteem, and autonomous functioning as a proxy for overall well-being.
Citation: Spielmans GI, Gerwig K. The Efficacy of Antidepressants on Overall Well-Being and Self-Reported Depression Symptom Severity in Youth: A Meta-Analysis. Psychother Psychosom 2014;83:158-164 (DOI:10.1159/000356191
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Artificial Intelligence: It's Time To Talk About What Emotions We Want AI To Have
- Most Idiotic Rejection Of Course From Philosopher Of Science Not Grasping Relativity
- Highlights From ICNFP 2015
- Lettuces Now, What Next - Could Astronauts Get All Their Oxygen And Food From Algae Or Plants?
- Innate GMO Potato Deregulated By USDA
- Brain Size Matters When It Comes To Remembering
- Alpha Lipoic Acid Dietary Supplement Slows Aging In Mice
- "I have a friend who has 2 Ph.D., one in nuclear physics and one in philosophy. His general observation..."
- "The top spin is indeed being measured, with results in agreement with standard model predictions..."
- "Without a magnetic field on Mars, it should be patently obvious that terraforming attempts would..."
- "For instance would it be possible to measure the g-factor of the top quark? A dirac particle should..."
- "Dr. Federoff is wrong about golden rice being tied up in the regulatory process for more than a..."
- “Shock Therapy” – Not a Cuckoo’s Nest, a Valid Depression Rx
- Innate: Simplot genetically engineered potato gets USDA nod for deregulation
- Sorry, AIDS Deniers, It’s Only a Headline
- Mission Not Yet Accomplished on Vaccines
- Cigarettes, Now With An Organic Health Halo
- Bee Wary of Tales of the ‘Beepocalypse’
- Pollution and weather influence heart attack outcomes?
- Fish oil diet versus gut microbes
- Naps linked to reduced blood pressure and fewer medications
- Why girls are less interested in computer science: Classrooms are too 'geeky'
- Frogs make irrational choices - and what means for understanding animal mating