Recent meta-analyses of the efficacy of second-generation antidepressants for youth have concluded that they possess anadvantage over placebo in terms of clinician-rated depressive symptoms, but no meta-analysis has included measures of quality of life, global mental health, self-esteem, or autonomy. Prior meta-analyses also did not include self-reports of depressive symptoms.
A recent article published in Psychotherapy and Psychosomatics reviewed the literature to understand the effects of antidepressant drugs on well-being in children and adolescents.
Results showed a non-significant difference between second-generation antidepressants and placebo in terms of self-reported depressive symptoms. Further, pooled across measures of quality of life, global mental health, self-esteem, and autonomy, antidepressants yielded no significant advantage over placebo.
Even though limited by a small number of trials, this analysis suggests that antidepressants offer little to no benefit in improving overall well-being among depressed children and adolescents.
The studies were selected through searching Medline, PsycINFO, and the Cochrane Central Register for Controlled Trials databases as well as GlaxoSmithKline's online trial registry, including self-reports of depressive symptoms and pooled measures of quality of life, global mental health, self-esteem, and autonomous functioning as a proxy for overall well-being.
Citation: Spielmans GI, Gerwig K. The Efficacy of Antidepressants on Overall Well-Being and Self-Reported Depression Symptom Severity in Youth: A Meta-Analysis. Psychother Psychosom 2014;83:158-164 (DOI:10.1159/000356191
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Are Marijuana Warning Labels Needed? Users Say Yes
- Should Pregnant Women Be Concerned About BPA?
- Something is wrong in the Arctic
- Order Patterned With Chaos - How Climate Is Predicted For Decades - With Exact Forecasts Only For Days
- The Five Stages Of A Dying Theory
- Is The X(5568) A True Resonance ?
- John Glenn, Astronaut, and Senator dead at 95. A Milennial Perspective
- "I was an avid reader of sci-fi and of non-fiction books about space exploration. I may have..."
- "I imagine a conversation something like this -Space agency executive: OK, John, we want you to..."
- "Vaughn A: thanks for your contribution.This swap-over effect was predicted back in about 1958. ..."
- "Emmanuel: if you use Microsoft Word to write an article, then copy it into science 2.0 like..."
- "No, not at all. I just posted there:..."
- Child Mummy May Change Timeline for Smallpox
- On Proposed Tanning Bed Ban for Teens, New Study Urges FDA to Act
- It’s Not Brain Surgery, But do you Know What is? Brain Surgery!
- A Possible Antidote for Carbon Monoxide Poisoning
- Surgeon General Declares War on E-Cigarettes But Not Marijuana, Hookah
- NHL's Concussion Protocol, a Closer Look (Part 2)