Recent meta-analyses of the efficacy of second-generation antidepressants for youth have concluded that they possess anadvantage over placebo in terms of clinician-rated depressive symptoms, but no meta-analysis has included measures of quality of life, global mental health, self-esteem, or autonomy. Prior meta-analyses also did not include self-reports of depressive symptoms.
A recent article published in Psychotherapy and Psychosomatics reviewed the literature to understand the effects of antidepressant drugs on well-being in children and adolescents.
Results showed a non-significant difference between second-generation antidepressants and placebo in terms of self-reported depressive symptoms. Further, pooled across measures of quality of life, global mental health, self-esteem, and autonomy, antidepressants yielded no significant advantage over placebo.
Even though limited by a small number of trials, this analysis suggests that antidepressants offer little to no benefit in improving overall well-being among depressed children and adolescents.
The studies were selected through searching Medline, PsycINFO, and the Cochrane Central Register for Controlled Trials databases as well as GlaxoSmithKline's online trial registry, including self-reports of depressive symptoms and pooled measures of quality of life, global mental health, self-esteem, and autonomous functioning as a proxy for overall well-being.
Citation: Spielmans GI, Gerwig K. The Efficacy of Antidepressants on Overall Well-Being and Self-Reported Depression Symptom Severity in Youth: A Meta-Analysis. Psychother Psychosom 2014;83:158-164 (DOI:10.1159/000356191
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Smoking, Drinking And Eating: It's Not About Your Freedom
- Part II: Bee Deaths And CCD - Flawed Chensheng Lu Harvard Studies Endanger Bees
- Coffee Lowers Risk Of Alzheimer's Up To 20 Percent
- Diversity Fatigue: Why Businesses Struggle To Close The Gender Gap
- Like Collaboration And Intelligence In Humans? Thank War
- A Disturbance In The Force: 'Giant' Charge Density Oscillation Discovered In Nanomaterials
- "How can diseases linked to smoking tobacco be on the rise when the smoking rate has been consistently..."
- "I was looking at The Winnower again this morning, which led me back here. I tried to comment on..."
- "There is no question they were created to cater to universities and are staffed by people from..."
- "And my second link should be not a copy of the first, but this: http://www.nature.com/news/half..."
- "Recently I saw The Conversation remove/censor legitimate comments arguing against an article written..."
- Behavioral interventions to prevent progression to diabetes equally effective in men and women
- Gender differences in adaptation to space flight
- Long-term complication rate low in nose job using patient's own rib cartilage
- Survival differences seen for advanced-stage laryngeal cancer
- Effect of once-daily, low-dose aspirin on heart attack deaths and other outcomes