Recent meta-analyses of the efficacy of second-generation antidepressants for youth have concluded that they possess anadvantage over placebo in terms of clinician-rated depressive symptoms, but no meta-analysis has included measures of quality of life, global mental health, self-esteem, or autonomy. Prior meta-analyses also did not include self-reports of depressive symptoms.
A recent article published in Psychotherapy and Psychosomatics reviewed the literature to understand the effects of antidepressant drugs on well-being in children and adolescents.
Results showed a non-significant difference between second-generation antidepressants and placebo in terms of self-reported depressive symptoms. Further, pooled across measures of quality of life, global mental health, self-esteem, and autonomy, antidepressants yielded no significant advantage over placebo.
Even though limited by a small number of trials, this analysis suggests that antidepressants offer little to no benefit in improving overall well-being among depressed children and adolescents.
The studies were selected through searching Medline, PsycINFO, and the Cochrane Central Register for Controlled Trials databases as well as GlaxoSmithKline's online trial registry, including self-reports of depressive symptoms and pooled measures of quality of life, global mental health, self-esteem, and autonomous functioning as a proxy for overall well-being.
Citation: Spielmans GI, Gerwig K. The Efficacy of Antidepressants on Overall Well-Being and Self-Reported Depression Symptom Severity in Youth: A Meta-Analysis. Psychother Psychosom 2014;83:158-164 (DOI:10.1159/000356191
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- The Era Of The Atom
- Can Moons Have Moonlets? Or Rings? Moonlets Of Pluto's Moons?
- Will Asteroid 2012 TC4 Hit Earth in October 2017?
- Thorium Can Serve As A Nuclear Fuel For Commercial Electricity Generation
- Numenta, The Bruce Lee of AI and Deep Learning
- Hubble's Successor Is 900 Percent Over Budget And A Decade Behind Schedule - Is Big Space In America Over?
- As Dawn Approaches, The First Color Images Of Ceres
- "Well there will always be things you could have done better with hindsight. Voyager 1's flyby of..."
- "That would be just enough to resolve a Dactyl sized moonlet of Hydra (1.2 by 1.4 by 1.6 km). The..."
- "With the exoplanets, then I've read that the ones that have gas giants near to the star would all..."
- "In the video they say the camera for the closest images of Pluto will have a resolution of a football..."
- "Indeed, there are several non-tidally locked moons! I must have misinterpreted something about..."