The sexual maturation of female mice has been linked to longevity by researchers.
They had previously established that mouse strains with lower circulating levels of the hormone IGF1 at age six months live longer than other strains. In new work, scientists report that females from strains with lower IGF1 levels also reach sexual maturity at a significantly later age.
The researchers conclude that IGF1 may co-regulate female sexual maturation and longevity. They showed that mouse strains derived from wild populations carry specific gene variants that delay sexual maturation, and they identified a candidate gene, Nrip1, involved in regulating sexual maturation that may also affect longevity by controlling IGF1 levels.
"This suggests a genetically regulated tradeoff—delayed reproduction but longer life—that is at least partially mediated by IGF1," says Jackson Laboratory researcher Rong Yuan, Ph.D.
Yuan notes that researchers in England recently showed that higher levels of IGF1 and other hormones in girls are associated with earlier age of menarche - onset of menstruation. In the new study, Yuan and colleagues used the biological benchmark of vaginal patency (VP) as indicator of sexual maturity in mice. Mice from the inbred strain C57BL/6J, also known as "Black 6," showed 9 percent lower IGF1, 6 percent delayed age of VP and 24 percent extended lifespan compared to a Black 6 substrain that carries a gene variation that increases IGF1.
Using haplotype mapping, researchers screened genetic and physiological data for 31 different inbred mouse strains and found genes that regulate female sexual maturation and lifespan, on Chromosomes 4 and 16. They showed that wild-derived mouse strains share a genetic profile associated with delayed VP and increased longevity, and identified a candidate gene, Nrip1, that controls IGF1 and age of VP.
Published in Proceedings of the National Academy of Sciences.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Researchers Created A Laser Bullet To See What It Would Look Like - And Here It Is
- Will Holding Thermal Printer Paper Really Send Your BPA Levels Soaring?
- The Quote Of The Week - Shocked And Disappointed
- As The Weather Changes, So Do Beliefs About Climate Change
- ECFA Workshop: Planning For The High Luminosity LHC
- Limiting Global Warming To 2°C: The Philosophy And The Science
- Great Earthquakes Doubled In The Most Recent 10 Year Period - What That Means
- "I have no time for you. Either learn how to have a decent, mature conversation without resorting..."
- "The past 12 months—October 2013–September 2014—was the warmest 12-month period among all..."
- "Do you really think science20 readers are all so stupid that they are going to fall for Climate..."
- "'Mememine' is a well known astro-turfer for the denial industry. He spams the same identical gish..."
- "I have heard (from someone who worked there) of a laboratory in a country far, far away where they..."
- National Wildlife Refuge System bans on GMOs and neonics lack transparency, scientific rationale
- Want better sperm? Eat more pesticides
- Beyond universal donors, some people are programed with no blood type at all
- Anti-conventional ag movement spurs Big Ag to look to organic pesticides
- Can people really inherit memories?
- An end to fat shaming? The 50 year DNA mystery of metabolic dysfunction may soon be solved
- New policymaking tool for shift to renewable energy
- Teens whose parents exert more psychological control have trouble with closeness, independence
- Two days later: Adolescents' conflicts with family spill over to school, vice versa
- Children in high-quality early childhood education are buffered from changes in family income
- 'Breath test' shows promise for diagnosing fungal pneumonia
Books By Writers Here