The sexual maturation of female mice has been linked to longevity by researchers.
They had previously established that mouse strains with lower circulating levels of the hormone IGF1 at age six months live longer than other strains. In new work, scientists report that females from strains with lower IGF1 levels also reach sexual maturity at a significantly later age.
The researchers conclude that IGF1 may co-regulate female sexual maturation and longevity. They showed that mouse strains derived from wild populations carry specific gene variants that delay sexual maturation, and they identified a candidate gene, Nrip1, involved in regulating sexual maturation that may also affect longevity by controlling IGF1 levels.
"This suggests a genetically regulated tradeoff—delayed reproduction but longer life—that is at least partially mediated by IGF1," says Jackson Laboratory researcher Rong Yuan, Ph.D.
Yuan notes that researchers in England recently showed that higher levels of IGF1 and other hormones in girls are associated with earlier age of menarche - onset of menstruation. In the new study, Yuan and colleagues used the biological benchmark of vaginal patency (VP) as indicator of sexual maturity in mice. Mice from the inbred strain C57BL/6J, also known as "Black 6," showed 9 percent lower IGF1, 6 percent delayed age of VP and 24 percent extended lifespan compared to a Black 6 substrain that carries a gene variation that increases IGF1.
Using haplotype mapping, researchers screened genetic and physiological data for 31 different inbred mouse strains and found genes that regulate female sexual maturation and lifespan, on Chromosomes 4 and 16. They showed that wild-derived mouse strains share a genetic profile associated with delayed VP and increased longevity, and identified a candidate gene, Nrip1, that controls IGF1 and age of VP.
Published in Proceedings of the National Academy of Sciences.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- How A Former Naturopath Can Help Unravel The Trickery of Alternative Medicine
- Swarm Bots Kill Mass Shooter
- Can A New Rule Trigger A Second EU Referendum? Petition 4 Millon Signatures, Nearly 12% Of Total Votes Cast
- Nanotech: The Most Dangerous Science Least Carefully Done
- A Billion Years Ago, What Did Earth's Ancient Magnetic Field Look Like?
- Finding All-Hadronic Top - Again
- How A Woman With Amnesia Defies Conventional Wisdom About Memory
- "Sorry, but even using the term allopath shows your bias. That is a term invented by the creator..."
- "Lets make something clear- most of you are arguing past each other on topics that are too broad..."
- "Hi Anlain, it explains on the page itself. It's a post vote survey - not a poll, so more accurate..."
- "If british elections and referenda are supposed to be secret ballots,how can statistics like those..."
- "If you really wanted to know the truth you could find many researched and peer reviewed articles..."
- DIY Biohacking: Unethical, Fringe, and Probably Necessary To Advance Science
- Summer Camp Means Fun for Kids, But Panic for Some Parents
- Swayed By Lunch Money: A Grotesque Insult to Doctors
- Sensing Too Much Zika Exposure, Golfers Continue Olympic Exodus
- Cannabis Beverages: A New Way to Get High
- Got Zika? Thank an Environmentalist
- Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells
- NIH-supported study pinpoints origin of 2009 H1N1 influenza pandemic
- The July 2016 issue of Geology is now online
- At the droplet of a hat: Capturing mixable liquid interaction
- Triple external quantum efficiencies -- a new material TADF was developed