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    Extra Virgin Olive Oil Protects Against Alzheimer's Disease - Study
    By News Staff | March 22nd 2013 11:03 AM | 10 comments | Print | E-mail | Track Comments

    Consumption of extra virgin olive oil has been linked to reduced risk of Alzheimer's disease (AD) and its benefit may lie in one component of olive oil that helps shuttle the abnormal AD proteins out of the brain.

    Alzheimer's disease affects about 30 million people worldwide but the prevalence is lower in Mediterranean countries - thus the correlation with olive oil. Scientists once attributed it to the high concentration of healthful monounsaturated fats in olive oil, which is consumed in large amounts in the Mediterranean diet.

    Recent research also suggested that the actual protective agent might be a substance called oleocanthal, which has effects that protect nerve cells from the kind of damage that occurs in AD. Kaddoumi's team sought evidence on whether oleocanthal helps decrease the accumulation of beta-amyloid (Aβ) in the brain, believed to be the culprit in AD.

     In their paper, Amal Kaddoumi and colleagues describe tracking the effects of oleocanthal in the brains and cultured brain cells of laboratory mice used as stand-ins for humans in such research. In both instances, oleocanthal showed a consistent pattern in which it boosted production of two proteins and key enzymes believed to be critical in removing Aβ from the brain.

    "Extra-virgin olive oil-derived oleocanthal associated with the consumption of Mediterranean diet has the potential to reduce the risk of AD or related neurodegenerative dementias," the report concludes.



     Published in ACS Chemical Neuroscience.

    Comments

    As a Senior citizen I am going to blame the seniors on this issue, here is why

    1. We are still waiting for Billion dollar big pharma drug makers to "give" them a drug to stop the illness. Big Phrama wants money and does not care about you

    2. To often Families do nothing but accept an Alzheimer's diagnoses but do not attempt to use natural cures. Instead they feel sorry for themselves or their loved ones

    3. Walks for the cure are a waste of time to make money, take the illness into your own hands See here http://malalzheimer.blogspot.com/2013/03/stop-waiting-for-drug-makers-to...

    Hank
    You found a cure for Alzheimer's and posted it on your blog?  You are going to get the biggest Nobel prize ever.
    Gerhard Adam
    So your solution is that everyone should send you $20 so that you can tell them the dietary secrets? 

    More snake oil.
    Mundus vult decipi
    John Hasenkam
    I'd love to believe there is a cure of Alz but once the condition has progressed to produce symptoms that seems highly unlikely. At best we might be able to achieve stabilisation but even that remains problematic. Over the last 12 months the research focus has shifted to identifying risk factors up to 20 years before the emergence of symptoms. The current drug approach works for a very few people but is based on findings from the 1970s! The target is to maintain acetylcholine levels by inhibiting ACHe but that does nothing to address the existing damage and there are even studies showing that the cannabinoids THC and CBD do a better job at inhibiting ACHe. But you can't patent a natural product sooo ... . 
    Bonny Bonobo alias Brat
    This article called 'Could trepanation be a viable treatment for dementia?' is quite interesting I think, I found a similar trepanation treatment for dementia article some time ago here at Science20 that I linked to in the comments section but can't remember which blog now and I can't be bothered to look, but I was hoping there would have been more scientific research results available by now, before I get dementia and completely forget about it.



    Detail from The Extraction of the Stone of Madness, a painting by Hieronymus Bosch depicting trepanation (c.1488-1516)

    'Trepanation, or drilling a hole in the skull, is an ancient medical treatment getting a new look for the treatment of some mental illnesses, including dementia.  The Beckley Foundation in Oxford has been seriously trying to use trepanation to treat dementia caused by Alzheimer’s or other reasons. The theory is that a hole in the skull improves blood circulation in the brain.  Just what role blood circulation has in causing dementia is unknown.'
    My latest forum article 'Australian Researchers Discover Potential Blue Green Algae Cause & Treatment of Motor Neuron Disease (MND)&(ALS)' Parkinsons's and Alzheimer's can be found at http://www.science20.com/forums/medicine
    John Hasenkam
    Just what role blood circulation has in causing dementia is unknown.'


    There has long been an association between atherosclerosis and alzheimers but causative processes remain obscure. Nonetheless clearly poor circulation is a contributing factor and high lipid values seem to accelerate amyloid desposition independently of atherosclerosis. 


    Trepanation simply relieves intra cranial pressure which is arises from injury and inflammation, with inflammation being a central component of alzheimers but I'm doubtful intra cranial pressure increase is a consequence of that. If people are now that desperate to seek out trepanation as a treatment modality that simply reflects our profound desperate ignorance about dementias generally. Waste of friggin time. 


    I have very little risk of dementia, completely absent in my family line. Perhaps that is a shame because I like the idea of forgetting so much of what I have learnt because so much of that is bullshit anyway. 
    Bonny Bonobo alias Brat
    Trepanation simply relieves intra cranial pressure which is arises from injury and inflammation, with inflammation being a central component of alzheimers but I'm doubtful intra cranial pressure increase is a consequence of that. If people are now that desperate to seek out trepanation as a treatment modality that simply reflects our profound desperate ignorance about dementias generally. Waste of friggin time.
    I think you are being rather unfairly scathing John about this being a waste of friggin time! Ive found the Science20 blog, it was called 'Neurotoxicity Of Anesthetics And Alzheimer's Disease'

    It makes a lot of sense that anaesthetics could be a potential neurotoxic risk factor playing a role in post-operative cognitive decline and illnesses such as Alzheimer's disease. Here is my original comment :-
    I had an operation and general anaesthetic earlier this year and seem to have lost a lot of my food appetite since that day, maybe I'm now on my way to getting Alzheimer's disease as a result? Probably, all I can do is keep doing those daily handstands in the swimming pool to keep my cerebrospinal fluid (CSF) moving, as CSF is supposed to keep the spine and the brain buoyant, protected, chemically stable and free from ischaemia, see http://en.wikipedia.org/wiki/Cerebrospinal_fluid This is a much more attractive alternative to trepanation, a possible future treatment for Alzheimer's disease, see http://boingboing.net/2009/06/18/trepanation-for-deme.html .I need that like a hole in the head, though there might be a few people who would like to administer it to me!



    Needless to say my food appetite returned. Here's a rather nice picture from Wikipedia of an MRI showing the cerebral spinal fluid pulsating nicely, it has been shown to be not pulsating nicely in a lot of Alzheimer patients..
    My latest forum article 'Australian Researchers Discover Potential Blue Green Algae Cause & Treatment of Motor Neuron Disease (MND)&(ALS)' Parkinsons's and Alzheimer's can be found at http://www.science20.com/forums/medicine
    John Hasenkam
    It makes a lot of sense that anaesthetics could be a potential neurotoxic risk factor playing a role in post-operative cognitive decline and illnesses such as Alzheimer's disease. 
    Yes I have seen some studies on this. It is not consistent, it depends on the age of the person, the type of anesthesia, and the lengthy of surgery. The exact reasons for this problem remain unclear if only because we still don't have a clear understanding of anaesthesia. At a broad swipe I suggest that it might simply be that surgery is a big shock to the body, generating systemic inflammation which helps pave the way for amyloid deposition. It could be related to energy metabolism, impacts on mitochondrial function are very strongly associated with amyloid deposition. It could be micro embolisms in the CNS arising from surgery(a big problem post cardiac surgery). It could be ...   



    I do not consider the risk of Alz from surgery to be that great Trepanation will require anesthesia. Choose your poison. 
    Bonny Bonobo alias Brat
    Actually John, trepanation doesn't require general anaesthesia, just a local anaesthetic. There are no pain receptors in the brain, look at the picture above :)
    My latest forum article 'Australian Researchers Discover Potential Blue Green Algae Cause & Treatment of Motor Neuron Disease (MND)&(ALS)' Parkinsons's and Alzheimer's can be found at http://www.science20.com/forums/medicine
    Gerhard Adam
    Yes, I believe that's why they're referred to as "numbskulls".
    Mundus vult decipi